A clinical study was done to discover whether or not Formalin-Guaiacol "NEO" (FG) could be used as disinfectant for intracanal medication. In 679 cases of pulpectomy and infected root canal, FG was sealed in the root canals for a few days, and clinical symptoms and progress were examined at the begining of the next appointment. The results obtained were as follows: 1. 8 out of 247 asymptomatic apical periodontitis cases resulted in exacerbation of periodontitis. 4 out of these 8 cases had both spontaneous pain and percussion pain. In the 4 remaining cases, only percussion pain was indicated. It was considered that these clinical symptoms were caused by FG. 2. It was concluded that FG could be used as disinfectant for intracanal medication in pulpectomy and infected root canal treatment teeth.