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内容記述 |
We examined the influence of lidocaine, mepivacaine, ropivacaine , bupivacaine , and levobupivacaine on skin blood flow in rabbits using a laser Doppler blood flowmeter. New Zealand White rabbits were anesthetized with sodium thiopental. 0.2 ml of 0.125～ 2.0% lidocaine, 0.125～3.0% mepivacaine, 0.125～0.75% ropivacaine, 0.125～0.5% bupivacaine, 0.125～0.75% levobupivacaine, 2.0% lidocaine with adrenaline (A) (1/80,000), and 3.0% propitocaine with felypressin (0.03 IU) were injected subcutaneously into the back skin of the rabbit’s. Physiological saline (0.2 ml) was injected as a control. We measured the skin blood flow using a laser Doppler blood flowmeter before and 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 9, and 10 minutes after the injection. The blood flow after the injection of each local anesthetic was converted into a percentage of the control value (before injection). The mean values of the skin blood flow before the injection in each group showed no significant differences. The skin blood flow was increased 30 seconds after the injection of physiological saline and showed no significant changes from 1 to 10 minutes after the injection. The skin blood flow was significantly increased by the subcutaneous injection of 0.125, 0.25, 0.5, 0.75, 1.0, and 2.0% lidocaine, 1.0, 2.0, and 3.0% mepivacaine, 0.125, 0.25, and 0.5% bupivacaine, and 0.75% levobupivacaine. The skin blood flow was significantly decreased by the injection of 0.125, 0.25, 0.5, and 0.75% mepivacaine, 0.125, 0.25, 0.5, and 0.75% ropivacaine, 0.125, 0.25, and 0.5% levobupivacaine. Lidocaine and bupivacaine increased the skin blood flow dependent on their concentration. On the other hand, ropivacaine decreased the skin blood flow dependent on its concentration. Mepivacaine decreased the skin blood flow at concentrations lower than 0.75% and increased it at a concentration higher than 1.0%. Levobupivacaine decreased the skin blood flow at concentrations lower than 0.5%, and increased it at those higher than 0.75%. The 0.5% bupivacaine and 2.0% lidocaine led to the most marked increase in skin blood flow, and 2.0% lidocaine−A and 0.75% ropivacaine led to the most marked decrease. |
matsumoto_shigaku39-2-04.pdf (1.1 MB)
