| Item type |
松本歯学/学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-03-07 |
| タイトル |
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タイトル |
Atelocollagen enhanced osteogenesis in a geometricstructured beta–TCP scaffold by VEGF induction. |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Honeycomb-shaped β-TCP |
| キーワード |
|
|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Atelocollagen |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
VEGF |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bone marrow mesenchymal stem cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Blood vessels |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bone regeneration |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
YAGAMI, KIMITOSHI
SADAOKA, SUNAO
NAKAMURA, HIROSHI
KOMATSU, SAHO
ONODERA, JUN
SUZUKI, MASAHIKO
KUBOKI, YOSHINORI
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In order to establish the convertibility of a host for bone augmentation, we herein developed a new honeycombshaped β-tricalcium phosphate (37H) using atelocollagen as a scaffold, which exhibited unique geometric properties for in vitro and in vivo studies.Human mesenchymal stem cells (MSC) were cultured with 37H or atelocollagen-coated honeycomb-shaped β-tricalcium phosphate (Col37H), and their osteoblastic differentiation was then analyzed. Atelocollagen promoted cell adhesion and formation of vessel-like structures in the tunnels of scaffolds of cultured MSC. The mRNA expression levels of type I collagen, osteocalcin, and VEGF were greater in MSC cultured with Col37H than with 37H. Bone generation with Col37H in the rat calvaria was greater than with 37H, and this was attributed to early vessel construction. A large number of blood vessels invaded tunnels from the periosteum and existing bone surface. A strong VEGF signal was detected immediately before the new bone surface in the tunnels of Col37H. These results indicate that the addition of atelocollagen to Col37H has potential in the construction of functional artificial bone. |
| 書誌情報 |
en : Journal of Tissue Science & Engineering
巻 7,
号 1:1000162,
発行日 2016-01-18
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| 出版者 |
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出版者 |
OMICS International |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2157-7552 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.4172/2157-7552.1000162 |
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関連名称 |
info:doi/10.4172/2157-7552.1000162 |
| 権利 |
|
|
権利情報 |
Copyright: © 2016 Yagami K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.(https://creativecommons.org/licenses/by/4.0/) |
| 情報源 |
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関連名称 |
雑誌掲載論文(電子版) |
| 関連サイト |
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識別子タイプ |
URI |
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|
関連識別子 |
https://www.omicsonline.org/open-access/atelocollagen-enhanced-osteogenesis-in-a-geometric-structured-betatcpscaffold-by-vegf-induction-2157-7552-1000162.php?aid=68248 |
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関連名称 |
OMICS International |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (2.5 MB)
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