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Pathological Examination of Experimentally Induced Periodontal Polyp in Mice Matsuda, Saeka Yokoi, Yukiko Moriyama, Keita Shoumura, Masahito Osuga, Naoto Nakano, Keisuke Kawakami, Toshiyuki Copyright © 2015 Matsuda, S et al The Hard Tissue Biology Network Association Periodontal polyp Micro-CT Histopathology Experimental model application/pdf The mechanism in the formation of periodontal polyp has been established in several histological studies but details on cell differentiation and/or proliferation have not been elucidated. In the present study, we established a convenient and possible experimental system using ddY mice. Briefly, pentobarbital sodium (Somnopentyl) was injected into the abdominal cavity of the mouse followed by access cavity preparation on maxillary first molar using low speed ½ round bur (Merufa Inc), exposing the pulp and then allowed to perforate the floor of the pulp chamber. Observation was done over time until 6 months using micro CT (m_CT) image photography. Results with transmission image using m_CT showed the expansion in the width of the periodontal ligament in the furcation area. The lesion was excised as one mass and examined histopathologically. The granulation tissue was covered with stratified squamous epithelium. The present experimental technique has been confirmed to be effective in analyzing the formation of periodontal polyp induced by mechanical perforation. The Hard Tissue Biology Network Association(JHTBNet) 2015-10 eng journal article VoR https://mdu.repo.nii.ac.jp/records/2556 https://doi.org/10.2485/jhtb.24.397 info:doi/10.2485/jhtb.24.397 雑誌掲載論文(電子版) http://doi.org/10.2485/jhtb.24.397 J-STAGE Free 2016247360 AA11074332 1341-7649 Journal of Hard Tissue Biology 24 4 397 400 https://mdu.repo.nii.ac.jp/record/2556/files/2016-ja-003.pdf application/pdf 556.5 kB 2016-09-29