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塩化第二水銀のラット肝薬物代謝酵素に対する作用 The Effect of Mercuric Choride on Drug-Metabolizing Enzymes in Rat Liver 倉橋, 寿 application/pdf The effect of mercuric chloride on drug-metabolizing enzymes in rat liver was studied in vivo and in vitro. In the in vitro study, when mercury was added to the incubation mixtures, all enzymes were inhibited. Fifty per cent inhibitory rate was 52 ppm on aminopyrine demethylase, 72 ppm on aniline hydroxylase, 96 ppm on hexobarbital oxidase respectively. In the in vivo study, when rats were ingested mercuric chloride in their drinking water for a month, the quantity of drinking water was decreased against the increase of mercury concentration. Body weight and liver-body weight ratio were also decreased. The concentration of mercury in rat liver was increased in direct proportion to the each quantity of mercury ingestion. Aminopyrine demethylase, aniline hydroxylase and hexobarbital oxidase were all inhibited as well. The inhibition was stronger in vivo under the same mercury concentration. 松本歯科大学学会 1981-12-31 jpn journal article VoR https://mdu.repo.nii.ac.jp/records/1699 AN00232590 0385-1613 松本歯学 7 2 194 198 https://mdu.repo.nii.ac.jp/record/1699/files/matsumoto_shigaku_07-02-03.pdf application/pdf 270.8 kB 2013-10-30