2026-03-06T14:20:07Z https://mdu.repo.nii.ac.jp/oai

oai:mdu.repo.nii.ac.jp:00000559 2023-06-19T08:35:36Z 1:32:121

Mystery of osteoclasts 破骨細胞の神秘 中村, 美どり 松浦, 幸子 宮沢, 裕夫 宇田川, 信之 骨化謝共役 破骨細胞 骨芽細胞 OPG 大理石骨病 application/pdf Deficiency of osteoprotegerin (OPG), a soluble decoy receptor for the receptor activator of NF-kB ligand (RANKL), in mice induces osteoporosis caused by enhanced bone resorption, but also accelerates bone formation. We examined whether bone formation is coupled with bone resorption in OPG-deficient (OPG^<-/->) mice delete using risedronate, an inhibitor of bone resorption. Histomorphometric analysis showed that bone formation-related parameters (e.g., mineral apposition rate and osteoblast surface/bone surface) in OPG^<-/-> mice sharply decreased with suppression of bone resorption by daily injection of risedronate for 30 days. OPG^<-/-> mice exhibited high serum alkaline phosphatase activity and osteocalcin concentration, both of which were decreased to the levels of wild-type mice by the risedronate injection. Serum levels of RANKL were markedly elevated in the OPG^<-/-> mice, but were unaffected by risedronate. These results suggest that bone formation is coupled with bone resorption at local sites in OPG^<-/-> mice, and that serum RANKL levels do not reflect this coupling. journal article 松本歯科大学学会 2004-04-30 VoR application/pdf 松本歯学 1 30 9 19 AN00232590 0385-1613 https://mdu.repo.nii.ac.jp/record/559/files/matsumoto_shigaku_30-01-02.pdf https://mdu.repo.nii.ac.jp/records/559 jpn