2026-03-07T09:12:41Z https://mdu.repo.nii.ac.jp/oai

oai:mdu.repo.nii.ac.jp:00001072 2023-06-19T08:22:49Z 1:44:87

塩化第一スズのカエル心筋攣縮に対する作用 Effect of Stannous Chloride on the Twitch of Frog Cardiac Muscle HATTORI, TOSHIMI MAEHASHI, HIROSHI stannous chloride calcíum channel cardiac muscle frog application/pdf Stannous chloride (SnCl_2) increases the calcium (Ca) entry into motor nerve terminals. Three kinds of Ca channels have been found in nerves (i.e., L-, N-, and T-types). To determine whether or not L-type Ca channels participate in the SnCl_2-induced increase in Ca entry, the effect of SnCl_2 on the twitch of the bullfrog auricular muscle was investigated and compared with that of the modulator selective to each type of the Ca channels. Both nifedipine (20μM) and nicardipine (20μM), L-type Ca channel blockers, inhibited the twitch. Although Bay K 8644 (20μM), a Ca agonist of the L-type Ca channels, augmented the twitch, SnCl_2 (0.1mM) did not. NiCl_2 (0.1mM), a T-type Ca channel blocker, had no effect on the twitch. The results obtained suggest that SnCl_2 may not activate the L-type Ca channels and that SnCl_2 might be likely to enhance the Ca entry into the motor nerve terminals by activating the N-type channels. journal article 松本歯科大学学会 1991-04-30 VoR application/pdf 松本歯学 1 17 20 24 AN00232590 0385-1613 https://mdu.repo.nii.ac.jp/record/1072/files/matsumoto_shigaku_17-01-02.pdf https://mdu.repo.nii.ac.jp/records/1072 eng