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Pathological Examination of Experimentally Induced Periodontal Polyp in Mice Matsuda, Saeka Yokoi, Yukiko Moriyama, Keita Shoumura, Masahito Osuga, Naoto Nakano, Keisuke Kawakami, Toshiyuki Periodontal polyp Micro-CT Histopathology Experimental model application/pdf The mechanism in the formation of periodontal polyp has been established in several histological studies but details on cell differentiation and/or proliferation have not been elucidated. In the present study, we established a convenient and possible experimental system using ddY mice. Briefly, pentobarbital sodium (Somnopentyl) was injected into the abdominal cavity of the mouse followed by access cavity preparation on maxillary first molar using low speed ½ round bur (Merufa Inc), exposing the pulp and then allowed to perforate the floor of the pulp chamber. Observation was done over time until 6 months using micro CT (m_CT) image photography. Results with transmission image using m_CT showed the expansion in the width of the periodontal ligament in the furcation area. The lesion was excised as one mass and examined histopathologically. The granulation tissue was covered with stratified squamous epithelium. The present experimental technique has been confirmed to be effective in analyzing the formation of periodontal polyp induced by mechanical perforation. journal article The Hard Tissue Biology Network Association(JHTBNet) 2015-10 VoR application/pdf Journal of Hard Tissue Biology 4 24 397 400 AA11074332 1341-7649 https://mdu.repo.nii.ac.jp/record/2556/files/2016-ja-003.pdf https://mdu.repo.nii.ac.jp/records/2556 eng info:doi/10.2485/jhtb.24.397 https://doi.org/10.2485/jhtb.24.397 雑誌掲載論文(電子版) J-STAGE Free http://doi.org/10.2485/jhtb.24.397 2016247360 Copyright © 2015 Matsuda, S et al The Hard Tissue Biology Network Association