{"created":"2023-06-19T07:38:02.125227+00:00","id":1011,"links":{},"metadata":{"_buckets":{"deposit":"4b2c3c41-5976-430a-b060-3afa3f22dcb1"},"_deposit":{"created_by":3,"id":"1011","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1011"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00001011","sets":["1:43:89"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Tissue Reactions to Squalane Embedded Subcutaneously in Rats"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"122","bibliographicPageStart":"117","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tissue reactions to subcutaneously embedded squalane fluid were histopathologically investigated, using twenty six female adult SD rats. The experimental periods ranged from one day to six weeks. The results are as follows: 1) No abnormalities appeared in the entire body of all experimental rats compared with the control animals by macroscopic observations during the experimental periods. 2) Histopathologically, granulation tissue formation with a slight inflammatory cell infiltration was elicited by the squalane fluid, although no degeneration and necrosis were recognized in the embedded area. 3) Some of the squalane were phagocytosed by macrophages in the granulation tissue, and no encapsulation was observed. 4) Accordingly, these data lead us to believe that squalane fluid is usable as a drug carrier inside the body.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川上, 敏行"},{"creatorName":"安東, 基善"},{"creatorName":"吉河, 靖"},{"creatorName":"宇治, 英世"},{"creatorName":"長谷川, 博雅"},{"creatorName":"枝, 重夫"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_18-02-02.pdf","filesize":[{"value":"958.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_18-02-02.pdf","url":"https://mdu.repo.nii.ac.jp/record/1011/files/matsumoto_shigaku_18-02-02.pdf"},"version_id":"333c5827-b621-44f6-b8dc-fc5e34c09d24"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"スクアラン","subitem_subject_scheme":"Other"},{"subitem_subject":"組織反応","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラットの皮下組織内に埋入したスクアランに対する組織反応","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラットの皮下組織内に埋入したスクアランに対する組織反応"}]},"item_type_id":"2","owner":"3","path":["89"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"1011","relation_version_is_last":true,"title":["ラットの皮下組織内に埋入したスクアランに対する組織反応"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:24:19.918367+00:00"}