{"created":"2023-06-19T07:38:08.057860+00:00","id":1101,"links":{},"metadata":{"_buckets":{"deposit":"9a7c2907-3e33-4f78-b0fe-97c89a61b63d"},"_deposit":{"created_by":3,"id":"1101","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1101"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00001101","sets":["1:45:83"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Metal Chelating Agents with Special Reference to DMSA and DMPS"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"132","bibliographicPageStart":"125","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2, 3-dimercaptosuccinic acid (DMSA) and 2, 3-dimercapto-1-propanesulfonic acid Na salt (DMPS), have been studied extensively by Aposhian's group as promising substitutes for 2, 3-dimercaptopropanol (BAL), a widely used antidote for arsenic (but which has been subject to controversy due to undesirable side effects when used clinically), as well as for possible use against mercury, lead, and other heavy metal intoxication. In contrast with BAL, both DMSA and DMPS show lower toxicity and are effective when administered orally. Many clinical trials have proved DMSA safe and well tolerated by patients. On the whole, the efficacy as antidotes is the same for both DMSA and DMPS. However, the LD_50 of DMSA in mammals is almost 3 times greater than that of DMPS. In arsenic poisoned rats, DMSA promoted excretion of arsenic via urine, while DMPS eliminated the poison through the bile. This difference in the route of elimination accords with pharmacokinetic studies showing that DMSA is distributed mainly extracellularly, and DMPS mainly intracellularly. These contrasting distributions explain the lower toxicity of DMSA compared with DMPS. Accordingly, of these two metal chelating agents, DMSA appears the more likely candidate to receive recommendation as a clinically useful drug in the future.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前橋, 浩"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_16-02-01.pdf","filesize":[{"value":"455.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_16-02-01.pdf","url":"https://mdu.repo.nii.ac.jp/record/1101/files/matsumoto_shigaku_16-02-01.pdf"},"version_id":"9d864276-ac8a-4ecd-a59d-b520138f06fe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DMSA","subitem_subject_scheme":"Other"},{"subitem_subject":"DMPS","subitem_subject_scheme":"Other"},{"subitem_subject":"重金属拮抗薬","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"有害金属拮抗薬DMSAおよびDMPSについて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"有害金属拮抗薬DMSAおよびDMPSについて"}]},"item_type_id":"2","owner":"3","path":["83"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"1101","relation_version_is_last":true,"title":["有害金属拮抗薬DMSAおよびDMPSについて"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:22:07.083743+00:00"}