@article{oai:mdu.repo.nii.ac.jp:00001290,
 author = {津田, 真 and 広瀬, 伊佐夫},
 issue = {3},
 journal = {松本歯学},
 month = {Dec},
 note = {application/pdf, We investigated the effects of lidocaine on the sympathetic reflex during tracheal intubation. Seventy three adult patients were divided into four groups as follows : group I : no administration of lidocaine (21 patients); group II : intravenous administration of lidocaine, 1.5 mg/kg (18 patients); group III : intravenous administration of lidocaine, 2.0 mg/kg (16 patients); group IV : intraepidural administration of lidocaine plus intravenous administration, 1.5-2.0 mg/kg (18 patients). The lidocaine was administered immediately before rapid induction using thiamylal 5 mg/kg and succinylcholine 1 mg/kg. As hemodynamic parameters, systolic and diastric blood pressure and heart rate were measured before induction, before laryngoscopy, and immediately after tracheal intubation. The incidence of arrhythmia during intubation was also observed in groups II and III. In all groups, both systolic and diastolic pressure fell and heart rate depressed slightly before the larygoscopy, and all the dynamic parameters elevated immediatly after intubation. We discovered no statistical significance between the groups. The incidence of arrhythmia was significantly low in II to III group. Our results suggest that neither intravenous nor intraepidural lidocaine depresses the sympathetic reflex, and also the that blockade in the efferent sympathetic pathway of the preganglionic lebel at T_7 to L_<1～4> has no effect on the neural reflex. However intravenous lidocaine at the dose of 1.5 mg/kg may be useful in the prevention of arrhythmia during laryngoscopy and tracheal intubation.},
 pages = {329--334},
 title = {リドカインの静注および硬膜外麻酔における気管内挿管時の循環動態に及ぼす影響},
 volume = {12},
 year = {1986}
}