@article{oai:mdu.repo.nii.ac.jp:00001330,
 author = {青, 久昭 and 大口, 弘和 and 佐原, 紀行 and 鈴木, 和夫},
 issue = {1},
 journal = {松本歯学},
 month = {Apr},
 note = {application/pdf, The purpose of the present study was to investigate the histologic responses to hydroxyapatite (HAP) ceramics particles. After the first and second premolar teeth in the mandibular ridges of adult dogs were surgically removed, HAP ceramics particles were placed in the fresh extraction sockets produced by extracting the first premolar teeth. The fresh extraction sockets of the second premolar teeth served as controls without implantation. Animals were sacrificed three months after implantation. The tissues on implant sites were examined by radiography and light microscopy. The results were summarized as follows. 1) Three months after implantation, a large number of HAP particles were surrounded by new bone. However, some HAP particles located in the central area of the implant sites were surrounded by connective tissues. 2) No detectable inflammation was observed in the tissues surrounding the implant, but osteoclastic cells and macrophages were occasionally found on the HAP ceramics surface. 3) Bone repairs on the implant sites were more delayed than those of contols. These results suggest that HAP ceramics particles have excellent tissue biocompatibility. However, further investigation is needed for clinical use.},
 pages = {52--59},
 title = {顆粒状Hydroxyapatite Ceramics塡塞による組織反応},
 volume = {12},
 year = {1986}
}