{"created":"2023-06-19T07:37:09.395827+00:00","id":156,"links":{},"metadata":{"_buckets":{"deposit":"3bd01d96-e062-448f-890e-7f672eb9414a"},"_deposit":{"created_by":3,"id":"156","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"156"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000156","sets":["1:7:53"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Effect of Sodium Fluoride on Hepatic Drug-Metabolizing Enzymes in Rats"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1977-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"21","bibliographicPageStart":"15","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of sodium fluoride (NaF) on drug-metabolizing enzymes (aminopyrine demethylase-AD, Hexobarbital oxidase-HO and aniline hydroxylase-AH) in the rat liver were studied in vivo and in vitro. Prior to the study, preliminary investigations were carried out on procedures of the enzyme assay concerning storage stability of these enzymes in a frozen 9,000×g supernatant fraction from the rat liver homogenate and whether nicotinamide should be involved in the incubation mixtures. Results are summarized as follows: 1) When a 9,000×g supernatant fraction was stored at -20℃, AD activity was decreased in 5 days to approx. 40% of the level of the first day, whereas both activities of AH and HO remained unchanged during the same period. 2) AD, AH and HO activities were all inhibited by the addition of nicotinamide when a higher concentration of NADP was maintained during the assay. In this study.nicotinamide was excluded from incubation mixtures. 3) In the in vitro study, when 0.1, 1, 10 and 100 mM of NaF was added to the incubation mixtures, AD and HO activities were both decreased In contrast, AH activity was slightly increased. 4) In the in vivo study, when rats ingested NaF (10, 38, 76 and 152ppm as F) in their drinking water for a month, it was observed that the sleeping time was prolonged by hexobarbital sodium, the fluoride was accumulated in the liver of these rats and HO activity was inhibited, but activities of AD and AH were both similar to those of control rats.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"倉橋, 寿"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-23"}],"displaytype":"detail","filename":"matsumoto_shigaku_03-01-03.pdf","filesize":[{"value":"432.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_03-01-03.pdf","url":"https://mdu.repo.nii.ac.jp/record/156/files/matsumoto_shigaku_03-01-03.pdf"},"version_id":"bc1b80c1-1be6-42af-92fd-ed3fce290c04"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"フッ化ナトリウムのラット肝薬物代謝酵素に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"フッ化ナトリウムのラット肝薬物代謝酵素に及ぼす影響"}]},"item_type_id":"2","owner":"3","path":["53"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-23"},"publish_date":"2012-05-23","publish_status":"0","recid":"156","relation_version_is_last":true,"title":["フッ化ナトリウムのラット肝薬物代謝酵素に及ぼす影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:44:28.629117+00:00"}