{"created":"2023-06-19T07:38:38.501675+00:00","id":1680,"links":{},"metadata":{"_buckets":{"deposit":"ebea3c08-15b3-4950-9ef9-c2274cea57a0"},"_deposit":{"created_by":17,"id":"1680","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"1680"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00001680","sets":["170:171"]},"author_link":["168","166","167","170","169"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"歯科矯正学的メカニカルストレスによるマウス歯根膜組織におけるHSPsの免疫組織化学的発現"}]},"item_10006_biblio_info_28":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-11-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"482","bibliographicPageStart":"475","bibliographicVolumeNumber":"15","bibliographic_titles":[{},{"bibliographic_title":"European Journal of Medical Research","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-08"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"松本歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"33602","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2011","subitem_description_type":"Other"}]},"item_10006_description_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_description":"甲第98号","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The histopathology of periodontal ligament of the mouse subjected to mechanical stress was studied. Immunohistochemical expressions of HSP27 and pHSP27 were examined. Experimental animals using the maxillary molars of ddY mouse by Waldo method were used in the study. A separator was inserted to induce mechanical stress. After 10 minutes, 20 minutes, 1 hour, 3 hours, 9 hours and 24 hours, the regional tissues were extracted, fixed in 4% paraformaldehyde and 0.05 M phosphate-buffered fixative solution. Paraffin sections were made for immunohistochemistry using HSP27 and p-HSP27. In the control group, the periodontal ligament fibroblasts expressed low HSP27 and p-HSP27. However, in the experimental group, periodontal ligament fibroblasts expressed HSP27 10 minutes after mechanical load application in the tension side. The strongest expression was detected 9 hours after inducing mechanical load. p-HSP27 was also expressed in a time-dependent manner though weaker than HSP27. The findings suggest that HSP27 and p-HSP27 were expressed for the maintenance of homeostasis of periodontal ligament by the activation of periodontal ligament fibroblasts on the tension side. It also suggests that these proteins act as molecular chaperones for osteoblast activation and maintenance of homeostasis.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_22":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第98号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PubMed Central® (PMC)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352656/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Biomed Central(BMC)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://eurjmedres.biomedcentral.com/articles/10.1186/2047-783X-15-11-475","subitem_relation_type_select":"URI"}}]},"item_10006_relation_16":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版 PubMed Central® (PMC))"}]}]},"item_10006_relation_23":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/21159572","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1186/2047-783X-15-11-475"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/2047-783X-15-11-475","subitem_relation_type_select":"DOI"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© I. Holzapfel Publishers 2010 ; This is an open access article distributed under the Creative Commons Attribution License(Attribution 2.0 Unported (CC BY 2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. "}]},"item_10006_source_id_27":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2047-783X","subitem_source_identifier_type":"ISSN"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MURAOKA, RINA"}],"nameIdentifiers":[{"nameIdentifier":"166","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKANO, KEISUKE"}],"nameIdentifiers":[{"nameIdentifier":"167","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KURIHARA, SABURO"}],"nameIdentifiers":[{"nameIdentifier":"168","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMADA, KAZUHIRO"}],"nameIdentifiers":[{"nameIdentifier":"169","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAWAKAMI, TOSHIYUKI"}],"nameIdentifiers":[{"nameIdentifier":"170","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-01-16"}],"displaytype":"detail","filename":"33602_A000114_honbun.pdf","filesize":[{"value":"4.3 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/1680/files/33602_A000114_honbun.pdf"},"version_id":"5eb3600f-27c5-4661-8b89-8ca17448473d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-01-16"}],"displaytype":"simple","filename":"2011_114_kou98.pdf","filesize":[{"value":"514.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨および審査の結果の要旨 ","url":"https://mdu.repo.nii.ac.jp/record/1680/files/2011_114_kou98.pdf"},"version_id":"b08be872-4356-401f-8c2f-9245d09ae99b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Heat shock protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HSP27","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"periodontal ligament cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mechanical stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"orthodontic tooth movement","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"17","path":["171"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-16"},"publish_date":"2013-06-16","publish_status":"0","recid":"1680","relation_version_is_last":true,"title":["Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-06-19T07:56:35.184811+00:00"}