{"created":"2023-06-19T07:38:39.615663+00:00","id":1699,"links":{},"metadata":{"_buckets":{"deposit":"20f2021e-8c90-40d7-8d24-858cd291f18c"},"_deposit":{"created_by":3,"id":"1699","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1699"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00001699","sets":["1:12:60"]},"author_link":["212"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Effect of Mercuric Choride on Drug-Metabolizing Enzymes in Rat Liver"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1981-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"198","bibliographicPageStart":"194","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of mercuric chloride on drug-metabolizing enzymes in rat liver was studied in vivo and in vitro. In the in vitro study, when mercury was added to the incubation mixtures, all enzymes were inhibited. Fifty per cent inhibitory rate was 52 ppm on aminopyrine demethylase, 72 ppm on aniline hydroxylase, 96 ppm on hexobarbital oxidase respectively. In the in vivo study, when rats were ingested mercuric chloride in their drinking water for a month, the quantity of drinking water was decreased against the increase of mercury concentration. Body weight and liver-body weight ratio were also decreased. The concentration of mercury in rat liver was increased in direct proportion to the each quantity of mercury ingestion. Aminopyrine demethylase, aniline hydroxylase and hexobarbital oxidase were all inhibited as well. The inhibition was stronger in vivo under the same mercury concentration.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"倉橋, 寿"}],"nameIdentifiers":[{"nameIdentifier":"212","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-10-30"}],"displaytype":"detail","filename":"matsumoto_shigaku_07-02-03.pdf","filesize":[{"value":"270.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_07-02-03.pdf","url":"https://mdu.repo.nii.ac.jp/record/1699/files/matsumoto_shigaku_07-02-03.pdf"},"version_id":"2f6ae4a5-7741-43d8-90d8-dd206d953e34"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"塩化第二水銀のラット肝薬物代謝酵素に対する作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"塩化第二水銀のラット肝薬物代謝酵素に対する作用"}]},"item_type_id":"2","owner":"3","path":["60"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-30"},"publish_date":"2013-10-30","publish_status":"0","recid":"1699","relation_version_is_last":true,"title":["塩化第二水銀のラット肝薬物代謝酵素に対する作用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:09:06.233793+00:00"}