{"created":"2023-06-19T07:38:43.075482+00:00","id":2230,"links":{},"metadata":{"_buckets":{"deposit":"6d8c0e8c-ce83-48e1-b0a7-df1e049dd23e"},"_deposit":{"created_by":3,"id":"2230","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2230"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002230","sets":["170:177"]},"author_link":["2132","2133"],"item_10006_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oki, Emi"}],"nameIdentifiers":[{}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-06"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"松本歯科大学"}],"subitem_degreegrantor_identifier":[{}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013","subitem_description_type":"Other"}]},"item_10006_description_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_description":"甲第145号","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、カプサイシン刺激による三叉神経節内の遺伝子発現変動について、特にイントロン領域から転写されるnoncoding RNAに注目し、検討を行った。マイクロアレイによる解析では、カプサイシン刺激により24種の配列に発現上昇が認められた。また、これら全てのRNA発現がRT-PCRにより確認された。さらに、real-time PCRによる定量的解析から、このうち8種（Chd2、Ankh、Gnas、Tra2α-1、Tra2α-2、Pik3ip1、Tcf4）の発現上昇が有意であることが明らかにされた。これらの結果から、カプサイシン刺激が三叉神経節細胞のイントロン領域に及ぶ遺伝子発現変動に影響を与えることが示された。","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_22":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第145号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大木, 絵美"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-07-22"}],"displaytype":"detail","filename":"33602_A000172_honbun.pdf","filesize":[{"value":"443.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2230/files/33602_A000172_honbun.pdf"},"version_id":"78ea5f17-4bdc-4462-a0a2-d90897717a03"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-07-22"}],"displaytype":"simple","filename":"33602_A000172_shinsa-yoshi.pdf","filesize":[{"value":"324.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨および審査の結果の要旨 ","url":"https://mdu.repo.nii.ac.jp/record/2230/files/33602_A000172_shinsa-yoshi.pdf"},"version_id":"e5ea4b0c-257c-4314-996f-a0696703c3b6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カプサイシン刺激","subitem_subject_scheme":"Other"},{"subitem_subject":"三叉神経節細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"イントロン領域","subitem_subject_scheme":"Other"},{"subitem_subject":"noncoding RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現動態","subitem_subject_scheme":"Other"},{"subitem_subject":"選択的スプライシング","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"三叉神経におけるカプサイシン刺激時の非コード領域における遺伝子発現動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"三叉神経におけるカプサイシン刺激時の非コード領域における遺伝子発現動態"}]},"item_type_id":"10006","owner":"3","path":["177"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-15"},"publish_date":"2014-07-15","publish_status":"0","recid":"2230","relation_version_is_last":true,"title":["三叉神経におけるカプサイシン刺激時の非コード領域における遺伝子発現動態"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T08:02:17.088720+00:00"}