{"created":"2023-06-19T07:38:43.448542+00:00","id":2237,"links":{},"metadata":{"_buckets":{"deposit":"a297bfd7-79ff-44de-b024-c7513730a083"},"_deposit":{"created_by":3,"id":"2237","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2237"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002237","sets":["170:177"]},"author_link":["2152","2155","2157","2156","2158","2154","2159","2153"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"向精神薬服用患者の突然死症例におけるカリウムイオンチャネルに関する分子生物学的解析：QT延長症候群関連遺伝子の多型が危険因子となり得るか？"}]},"item_10006_biblio_info_28":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"99","bibliographicPageStart":"95","bibliographicVolumeNumber":"59","bibliographic_titles":[{},{"bibliographic_title":"Journal of Human Genetics","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-06"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"松本歯科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013","subitem_description_type":"Other"}]},"item_10006_description_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_description":"甲第152号","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Psychotropic drugs can pose the risk of acquired long QT syndrome (LQTS). Unexpected autopsy-negative sudden death in patients taking psychotropic drugs may be associated with prolonged QT intervals and life-threatening arrhythmias. We analyzed genes that encode for cardiac ion channels and potentially associated with LQTS, examining specifically the potassium channel genes KCNQ1 and KCNH2 in 10 cases of sudden death involving patients administered psychotropic medication in which autopsy findings identified no clear cause of death. We amplified and sequenced all exons of KCNQ1 and KCNH2, identifying G643S, missense polymorphism in KCNQ1, in 6 of the 10 cases. A study analysis indicated that only 11% of 381 healthy Japanese individuals carry this polymorphism. Reports of previous functional analyses indicate that the G643S polymorphism in the KCNQ1 potassium channel protein causes mild IKs channel dysfunction. Our present study suggests that administering psychotropic drug therapy to individuals carrying the G643S polymorphism may heighten the risk of prolonged QT intervals and life-threatening arrhythmias. Thus, screening for the G643S polymorphism before prescribing psychotropic drugs may help reduce the risk of unexpected sudden death","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_22":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"33602甲第152号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版)"}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Nature Pub"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/jhg/journal/v59/n2/full/jhg2013125a.html","subitem_relation_type_select":"URI"}}]},"item_10006_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1038/jhg.2013.125"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/jhg.2013.125","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_25":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"40019987534","subitem_relation_type_select":"NAID"}}]},"item_10006_relation_26":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2014281260","subitem_relation_type_select":"ICHUSHI"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"copyright 2014 The Japan Society of Human Genetics All rights reserved 1434-5161/14"}]},"item_10006_source_id_27":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1435-232X","subitem_source_identifier_type":"ISSN"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kamei, Sayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Noriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harayama, Yuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nunotani, Miyako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatsu, Kanae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiozaki, Tetsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Tokutaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asamura, Hideki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-07-22"}],"displaytype":"simple","filename":"33602_A000179_shinsa-yoshi.pdf","filesize":[{"value":"317.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨および審査の結果の要旨","url":"https://mdu.repo.nii.ac.jp/record/2237/files/33602_A000179_shinsa-yoshi.pdf"},"version_id":"78feb678-aac3-4b79-900b-2add5f3ea405"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-14"}],"displaytype":"simple","filename":"33602_A000179_yoshi.pdf","filesize":[{"value":"140.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文の要旨","url":"https://mdu.repo.nii.ac.jp/record/2237/files/33602_A000179_yoshi.pdf"},"version_id":"05fc7470-68f9-494c-8f9d-3b2ecdb9bcf3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"KCNH2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"KCNQ1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"long QT syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"psychotropic drugs","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sudden death","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Molecular analysis of potassium ion channel genes in sudden death cases among patients administered psychotropic drug therapy: Are polymorphisms in LQT genes a potential risk factor?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular analysis of potassium ion channel genes in sudden death cases among patients administered psychotropic drug therapy: Are polymorphisms in LQT genes a potential risk factor?","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"3","path":["177"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-15"},"publish_date":"2014-07-15","publish_status":"0","recid":"2237","relation_version_is_last":true,"title":["Molecular analysis of potassium ion channel genes in sudden death cases among patients administered psychotropic drug therapy: Are polymorphisms in LQT genes a potential risk factor?"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:56:41.928908+00:00"}