{"created":"2023-06-19T07:38:45.259148+00:00","id":2279,"links":{},"metadata":{"_buckets":{"deposit":"921b1430-7e0d-4743-bf1c-9c71683fbce3"},"_deposit":{"created_by":3,"id":"2279","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2279"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002279","sets":["178:203","193:194:195","193:205:273","193:208:276","193:233:278","193:235:270","193:236:238"]},"author_link":["2371","2374","2369","2373","2372","2370"],"item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"LPS処理したヒト歯肉線維芽細胞の炎症反応に及ぼす漢方薬小柴胡湯の予防効果"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1144","bibliographicPageStart":"1141","bibliographicVolumeNumber":"31","bibliographic_titles":[{},{"bibliographic_title":"Biological and Pharmaceutical Bulletin","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the present study, we investigated the anti-inflammatory effects of a Kampo medicine Shosaikoto (TJ-9) using in vitro periodontal disease model, in which human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS) from Porphyromonas gingivalis (PgLPS) produce IL-6, IL-8 and prostaglandin E2 (PGE2). Treatment with PgLPS (10 ng/ml), TJ-9 (up to 1 mg/ml) and their combinations for 24 h did not affect the viability of HGFs. Moreover, TJ-9 did not alter LPS-induced IL-6 and IL-8 productions. However, TJ-9 significantly suppressed LPS-induced PGE2 production in a dose-dependent manner but TJ-9 alone did not affect basal PGE2 level. Western blotting demonstrated that TJ-9 decreased cyclooxygenase-2 (COX-2) expression in a dosedependent manner but not phospholipase A2. Moreover, TJ-9 selectively and dose-dependently inhibited COX-2 activity. These results suggest that TJ-9 decreased PGE2 production by inhibition of both COX-2 expression and activity and that TJ-9 may be useful to improve gingival inflammation in periodontal disease.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan"}]},"item_10001_relation_12":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110006684330","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/18520044","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1248/bpb.31.1141 "}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1248/bpb.31.1141","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"J-STAGE"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1248/bpb.31.1141","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_24":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2008327109","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copy right © THE PHARMACEUTICAL SOCIETY OF JAPAN 2008 "}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-5215","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ARA, TOSHIAKI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MAEDA, YOSHIHIRO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJINAMI, YOSHIAKI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMAMURA, YASUHIRO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HATTORI, TOSHIMI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WANG, PAO-LI"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-10-06"}],"displaytype":"detail","filename":"2014-004_JA.pdf","filesize":[{"value":"156.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2014-004_JA.pdf","url":"https://mdu.repo.nii.ac.jp/record/2279/files/2014-004_JA.pdf"},"version_id":"64a9c711-9af9-4d81-9b40-caacbdd83337"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Shosaikoto","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"periodontal disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gingival fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lipopolysaccharide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-Inflammatory Agents, Non-Steroidal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drugs, Chinese Herbal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gingiva","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipopolysaccharides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Medicine, Kampo","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Preventive effects of a Kampo Medicine, Shosaikoto, on inflammatory responses in LPS-Treated Human gingival fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Preventive effects of a Kampo Medicine, Shosaikoto, on inflammatory responses in LPS-Treated Human gingival fibroblasts","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["195","203","238","270","273","276","278"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-06"},"publish_date":"2014-10-06","publish_status":"0","recid":"2279","relation_version_is_last":true,"title":["Preventive effects of a Kampo Medicine, Shosaikoto, on inflammatory responses in LPS-Treated Human gingival fibroblasts"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:58:56.947957+00:00"}