@article{oai:mdu.repo.nii.ac.jp:00002280,
 author = {ARA, TOSHIAKI and FUJINAMI, YOSHIAKI and IMAMURA, YASUHIRO and WANG, PAO-LI},
 issue = {3},
 journal = {Journal of Hard Tissue Biology},
 month = {Oct},
 note = {application/pdf, The aim of this study was to examine whether human gingival fibroblasts (HGFs) sustain to produce prostaglandin E2 (PGE2) in the presence of lipopolysaccharide (LPS). HGFs were treated with or without 10 ng/ml of LPS from Porphyromonas gingivalis (PgLPS) for 7 days collecting the culture supernatants for every 24 h, and PGE2 concentration in the supernatants was measured by ELISA. HGFs produced PGE2 at low level without PgLPS treatment. In contrast, HGFs continuously produce PGE2 with PgLPS treatment. At each day, the amount of PGE2 production by HGFs with PgLPS treatment was higher than that without treatment. These results demonstrate that the characteristic of HGFs, which continuously produce PGE2 in the presence of LPS, sustains inflammatory response in periodontal disease.},
 pages = {121--124},
 title = {Lipopolysaccharide-Treated Human Gingival Fibroblasts Continuously Produce PGE2},
 volume = {17},
 year = {2008}
}