@book{oai:mdu.repo.nii.ac.jp:00002313, author = {SHIBUYA, TOSHIYUKI and YUMII, TOSHIRO and TERAMOTO, SHINZO and KAWAKAMI, TOSHIYUKI}, month = {}, note = {9784905130062, application/pdf, To improve the paste used for root canal filling, the authors performed a histopathological study on 100 root canals from dogs of more than twelve months of age. The pulps were exposed under general anesthesia with the administration of pentobarbital sodium. The pulp chambers were left opened for one month and then enlargement and cleaning of the root canals were performed. The subjects were divided into three experimental groups: (A) 40 cases of root canals filled with a prepared paste called Vitapex, which contains calcium hydroxide, iodoform, silicone oil, and other substances (B) 30 cases of root canals filled with a paste called Calvital, a mixture of a powder containing calcium hydroxide, iodoform, guanofracin, and sulfathiazole, with a liquid containing propyleneglycol, distilled water and T-cain (C) 30 cases of unfilled root canals Only the pulp chambers were filled with cement bases and amalgam for all cases. After three months, the dogs were sacrificed and specimens were prepared for pathological examination. Radiographic examination was also carried out. The results are as follows. In most of the cases with root canal fillings containing Vitapex and Calvital, regeneration of alveolar bone and apical hard tissue as well as cicatrization of the periodontal membrane and the deep alveolar area were observed. Sealing of the perforated portion of the apex was observed less often. These two pastes proved to be clinically useful, whereas in cases in which no root canal filling was made, reparative process in the tissue of any kind was rarely observed. In many cases of Vitapex fillings and in some cases of Calvital fillings, regeneration of the alveolar bone was irregular and porous. Filling with either of the two pastes decreased the inflammation in the apical area. Three months after the experiment, radiopacity persisted in the group of cases in which Vitapex was used, while this persistence was less notable in cases filled with Calvital., Editor, Toshiyuki Kawakami, Language Editor, David M Carlson, viii, 232 p. ill. (some col.)}, publisher = {IDP Publishers}, title = {Chapter 10 : Histopathological Evaluation of Root Canal Filling Material Pastes: An Animal Study}, year = {2012} }