{"created":"2023-06-19T07:38:50.617085+00:00","id":2439,"links":{},"metadata":{"_buckets":{"deposit":"581aa02d-2247-4c39-8ec7-5eb51e492b6e"},"_deposit":{"created_by":3,"id":"2439","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2439"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002439","sets":["170:223"]},"author_link":["2883","2884"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"骨再生研究モデルとしての免疫正常および免疫不全動物の比較について"}]},"item_10006_biblio_info_28":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"592","bibliographicPageStart":"583","bibliographicVolumeNumber":"21","bibliographic_titles":[{},{"bibliographic_title":"Oral diseases","bibliographic_titleLang":"en"}]}]},"item_10006_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"張, 以鳴"}],"nameIdentifiers":[{}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-05-14"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"松本歯科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2015","subitem_description_type":"Other"}]},"item_10006_description_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_description":"甲第172号 ","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives To understand the differences and similarities between immunocompetent and immunodeficient mice as ectopic transplantation animal models for bone tissue engineering. Materials and Methods Osteogenic cells from mouse leg bones were cultured, seeded on β- TCP granules, and transplanted onto the backs of either immunocompetent or immunodeficient nude mice. At 1, 2, 4, and 8 weeks postoperatively, samples were harvested and evaluated by hematoxylin-eosin staining, tartrate-resistant acid phosphatase ( TRAP) staining, and immunohistochemical staining and quantitative PCR. Results In immunocompetent mice, inflammatory cell infiltration was evident at 1 week postoperatively and relatively higher expression of TNF- α and IL-4 was observed. In immunodeficient mice, new bone area and the number of TRAP-positive cells were larger at 4 weeks than in immunocompetent mice. The volume of new bone area in immunodeficient mice was reduced by 8 weeks. Conclusions Bone regeneration was feasible in immunocompetent mice. However, some differences were observed between immunocompetent and immunodeficient mice in the bone regeneration process possibly due to different cytokine expression, which should be considered when utilizing in vivo animal models. ","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_22":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"33602甲第172号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Wiley Online Library"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://onlinelibrary.wiley.com/doi/10.1111/odi.12319/abstract","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"EBSCO HOST"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://search.ebscohost.com/login.aspx?direct=true&db=ddh&AN=103030936&lang=ja&site=ehost-live","subitem_relation_type_select":"URI"}}]},"item_10006_relation_23":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/25648203","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1111/odi.12319"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/odi.12319","subitem_relation_type_select":"DOI"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 John Wiley & Sons A/S."}]},"item_10006_source_id_27":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1354-523X","subitem_source_identifier_type":"ISSN"}]},"item_10006_source_id_29":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11044105","subitem_source_identifier_type":"NCID"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang,  Yiming"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-18"}],"displaytype":"simple","filename":"33602_A000202_shinsa-yoshi.pdf","filesize":[{"value":"246.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文審査の結果及び最終試験の結果の要旨","url":"https://mdu.repo.nii.ac.jp/record/2439/files/33602_A000202_shinsa-yoshi.pdf"},"version_id":"9d80f742-0e4a-41e2-a1c6-02d7b765b647"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-13"}],"displaytype":"simple","filename":"33602_A000202_yoshi.pdf","filesize":[{"value":"169.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文の要旨","url":"https://mdu.repo.nii.ac.jp/record/2439/files/33602_A000202_yoshi.pdf"},"version_id":"0b67e847-8546-416e-a2ae-28ae5391829c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bone tissue engineering","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"animal models","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ectopic transplantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunological reaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nude mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Comparing immunocompetent and immunodeficient mice as animal models for bone tissue engineering","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparing immunocompetent and immunodeficient mice as animal models for bone tissue engineering","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"3","path":["223"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-26"},"publish_date":"2015-10-26","publish_status":"0","recid":"2439","relation_version_is_last":true,"title":["Comparing immunocompetent and immunodeficient mice as animal models for bone tissue engineering"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:51:24.279672+00:00"}