{"created":"2023-06-19T07:38:50.686436+00:00","id":2440,"links":{},"metadata":{"_buckets":{"deposit":"b1dfbd2e-03e2-4e79-b10b-4109872810e9"},"_deposit":{"created_by":3,"id":"2440","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2440"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002440","sets":["170:223"]},"author_link":["2885"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ダイナミン阻害剤ダイナソアは破骨細胞のアクチンリングを速やかに破壊することで骨吸収を抑制する"}]},"item_10006_biblio_info_28":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"400","bibliographicPageStart":"395","bibliographicVolumeNumber":"34","bibliographic_titles":[{},{"bibliographic_title":"Journal of bone and mineral metabolism","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-10"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"松本歯科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2015","subitem_description_type":"Other"}]},"item_10006_description_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_description":"甲第173号 ","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The cytoskeletal organization of osteoclasts is required for bone resorption. Binding of dynamin with guanosine triphosphate (GTP) was previously suggested to be required for the organization of the actin cytoskeleton. However, the role of the GTPase activity of dynamin in the organization of the actin cytoskeleton as well as in the bone-resorbing activity of osteoclasts remains unclear. This study investigated the effects of dynasore, an inhibitor of the GTPase activity of dynamin, on the bone-resorbing activity of and actin ring formation in mouse osteoclasts in vitro and in vivo. Dynasore inhibited the formation of resorption pits in osteoclast cultures by suppressing actin ring formation and rapidly disrupting actin rings in osteoclasts. A time-lapse image analysis showed that dynasore shrank actin rings in osteoclasts within 30 min. The intraperitoneal administration of dynasore inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced trabecular bone loss in mouse femurs. These in vitro and in vivo results suggest that the GTPase activity of dynamin is critical for the bone-resorbing activity of osteoclasts and that dynasore is a seed for the development of novel anti-resorbing agents.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_22":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"33602甲第173号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Springer LINK"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://link.springer.com/article/10.1007%2Fs00774-015-0683-1","subitem_relation_type_select":"URI"}}]},"item_10006_relation_23":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/26063501","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1007/s00774-015-0683-1"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00774-015-0683-1","subitem_relation_type_select":"DOI"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Japanese Society for Bone and Mineral Research and Springer Japan 2015"}]},"item_10006_source_id_27":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-8779 ","subitem_source_identifier_type":"ISSN"}]},"item_10006_source_id_29":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10747551","subitem_source_identifier_type":"NCID"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Thirukonda,  Gnanasagar Janardhanan"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-18"}],"displaytype":"simple","filename":"33602_A000203_shinsa-yoshi.pdf","filesize":[{"value":"135.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文審査の結果及び最終試験の結果の要旨","url":"https://mdu.repo.nii.ac.jp/record/2440/files/33602_A000203_shinsa-yoshi.pdf"},"version_id":"a2cd585b-7420-4668-8ebe-12a8ad666ace"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-13"}],"displaytype":"simple","filename":"33602_A000203_yoshi.pdf","filesize":[{"value":"118.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文の要旨","url":"https://mdu.repo.nii.ac.jp/record/2440/files/33602_A000203_yoshi.pdf"},"version_id":"ec23f07e-ebfc-4c68-b182-fc83f491c510"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Osteoclast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Actin ring","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone resorption","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dynamin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dynasore","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"3","path":["223"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-26"},"publish_date":"2015-10-26","publish_status":"0","recid":"2440","relation_version_is_last":true,"title":["The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:56:57.182395+00:00"}