{"created":"2023-06-19T07:38:50.896302+00:00","id":2444,"links":{},"metadata":{"_buckets":{"deposit":"4d708c00-ed2e-4b22-bff2-fd2b3f3975ca"},"_deposit":{"created_by":3,"id":"2444","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2444"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002444","sets":["178:204","193:201:202","193:206:210","193:208:256","193:233:257","193:242:243"]},"author_link":["2906","2907","2904","2909","2905","2908"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"438","bibliographicPageStart":"435","bibliographicVolumeNumber":"23","bibliographic_titles":[{},{"bibliographic_title":"Journal of Hard Tissue Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mouse subcutaneous tissue reaction to an embedded calcium hydroxide-based root canal filling material was analyzed histopathologically. After the material was placed within the mouse dorsal subcutaneous tissues, we performed examinations using histopathological, histochemical and immunohistochemical techniques. Two weeks after embedment, the proliferation of granulation tissue had already begun to surround the calcification.\nMost of the cells observed were macrophages. Likewise, multinucleated giant cells increased significantly. The multinucleated giant cells were observed as two types. In one, the centers of the giant cells were vacuoles, while in the others there were deeply stained calcifications with hematoxylin. Twelve weeks after embedment of the materials, further growth of multinucleated giants cells were sighted. Histochemically, von Kossa-stainpositive granules were observed within the macrophages and multinucleated giant cells as black fine granules. According to the TRAP stained specimens, the multinucleated giant cells especially reacted strongly at 4 weeks. However, the reaction became very weak at 12 weeks. CD68 immunohistochemical staining showed positive reactions in the cytoplasm of the proliferating macrophages and multinucleated giant cells. These results suggest that multinucleated giant cells are present in the surrounding tissues due to implantation of the calcium hydroxidebased root canal filling material, and that the presence of ACP in the cells is due to ingested calcium during active phagocytosis, which would disappear later on.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Hard Tissue Biology Network Association(JHTBNet) "}]},"item_10001_relation_12":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130004700428","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.2485/jhtb.23.435"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.23.435","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Jstage"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.2485/jhtb.23.435","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_24":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2015325366","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2014 Shoumura M et al by The Hard Tissue Biology Network Association(JHTBNet) "}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11074332","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-7649","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shoumura,  M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda,  S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osuga,  N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano,  K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsujigiwa,  H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami,  T"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-12-01"}],"displaytype":"detail","filename":"2015-ja-004.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2015-ja-004.pdf","url":"https://mdu.repo.nii.ac.jp/record/2444/files/2015-ja-004.pdf"},"version_id":"a1dbbe5a-001d-463d-b69a-d0529d6cf24f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Calcium hydroxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tissue reaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multi nucleated giant cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TRAP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mouse subcutaneous tissue reaction to calcium hydroxide-based.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mouse subcutaneous tissue reaction to calcium hydroxide-based.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["202","204","210","243","256","257"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-01"},"publish_date":"2015-12-01","publish_status":"0","recid":"2444","relation_version_is_last":true,"title":["Mouse subcutaneous tissue reaction to calcium hydroxide-based."],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:59:17.906951+00:00"}