{"created":"2023-06-19T07:37:15.152167+00:00","id":264,"links":{},"metadata":{"_buckets":{"deposit":"6ffbe751-314c-417b-a0ce-6a10234f5662"},"_deposit":{"created_by":3,"id":"264","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"264"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000264","sets":["1:11:58"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Augmentation of Skeletal Muscle Contraction by NaF"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1980-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"160","bibliographicPageStart":"153","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"For the purpose of elucidation of the mechanism of convulsion induced as the acute intoxication of sodium fluoride (NaF), the actions of NaF on the frog sciatic nerve-sar-torius muscle preparation were investigated electrophysiologically. The results obtained were summarised as follows: 1) Both twitch and tetanus tension were augmented by NaF dose-dependently. 2) NaF had little effect on the compound action potential of nerves, resting membrane potential, action potential and membrane resistance of muscle fibre. 3) NaF augmented the amplitude, rate of rise and half decay time of endplate potential dose-dependently. 4) NaF augmented both the frequency and the amplitude of miniature endplate potential (MEPP). 5) The amount of neostigmine which inhibits more than 80% of cholinesterases had no effect on the action of NaF on MEPP amplitude. These results suggest that NaF facilitates acetylcholine release from the presynaptic membrane, sensitizes the cholinergic receptor of the postsynaptic membrane and inhibits the cholinesterase in the neuromuscular junction, and that these actions of NaF are involved in augmentation of muscle contraction and the convulsion.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"服部, 敏己"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-23"}],"displaytype":"detail","filename":"matsumoto_shigaku_06-02-02.pdf","filesize":[{"value":"452.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_06-02-02.pdf","url":"https://mdu.repo.nii.ac.jp/record/264/files/matsumoto_shigaku_06-02-02.pdf"},"version_id":"6f0bc989-a6a3-4f0c-927b-b133fbbe4c54"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"骨格筋におけるNaFの収縮増強作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨格筋におけるNaFの収縮増強作用"}]},"item_type_id":"2","owner":"3","path":["58"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-23"},"publish_date":"2012-05-23","publish_status":"0","recid":"264","relation_version_is_last":true,"title":["骨格筋におけるNaFの収縮増強作用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:41:52.814435+00:00"}