{"created":"2023-06-19T07:39:01.921740+00:00","id":2685,"links":{},"metadata":{"_buckets":{"deposit":"c919bf11-c1a4-4c89-93ac-5460eda7e696"},"_deposit":{"created_by":3,"id":"2685","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2685"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002685","sets":["178:375","193:201:202","193:206:210","193:208:256","193:208:298","193:233:257","193:242:243"]},"author_link":["3775","3779","3780","3776","3778","3777","3781","3783","3782"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"001","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"S9","bibliographic_titles":[{},{"bibliographic_title":"International Journal of Dentistry and Oral Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cyto-pathological features of the periodontal ligament tissue inflammatory lesions have somehow been carried out but detailed cellular dynamics remain unclear. Therefore, in this review, we overviewed mainly our recent experimental model studies. That is performed using using ordinary ddY mice and BMP bone marrow transplanted mouse model. Regaring the experimental apical inflammatory periodontitis, at four weeks, micro-CT confirmed the presence of a radiolucent image at the apex of the tooth, which was then removed for histological examination. The results showed granulation tissue with fibrosis gradually formed at the periphery of an abscess. Next, if perforation were large, granulation tissue would grow to form periodontal polyp. Results of micro-CT revealed alveolar bone resorption and widening of periodontal ligament. Histopathological examination showed proliferation of fibroblasts with some round cells and blood vessels in the granulation tissue. Double immunofluorescent staining of GFP and Runx2 revealed that both proteins were expressed in spindle-shaped cells. Double immunofluorescent staining of GFP and CD31 revealed that both proteins were expressed in vascular endothelial cells in morphologically distinct vessels. The results suggest that fibroblasts, periodontal ligament fibroblasts and blood vessels in granulation tissue were derived from transplanted-bone marrow cells. Thus, essential growth of granulation tissue in periodontal polyp was caused by the migration of undifferentiated mesenchymal cells derived from bone marrow, which differentiated into fibroblasts and later on differentiated into other cells in response to injury.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SciDoc Publishers"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.19070/2377-8075-SI09001"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.19070/2377-8075-SI09001","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"SciDoc Publishers"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://scidoc.org/IJDOSS9.php","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright: Kawakami T© 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distributionand reproduction in any medium, provided the original author and source are credited."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2377-8075","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MATSUDA, SAEKA"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKANO, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUJIGIWA, H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKABATAKE, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKAFUJI, N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHOUMURA, M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OSUGA, N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAGATSUKA, H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWAKAMI, T"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-07"}],"displaytype":"detail","filename":"2017-ja-007.pdf","filesize":[{"value":"873.7 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2685/files/2017-ja-007.pdf"},"version_id":"c015a2b4-dded-4d97-8f66-25dc65e29e8d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chronic Apical Periodontitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alveolar Abscess","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronic Proliferelative Periodontal Inflammatory Lesion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontal Polyp","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Granulation Tissue","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontal Ligament","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Migration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Undifferentiated Mesenchymal Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone Marrow","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Overview of Cytological Dynamics of Periodontal Ligament Inflammatory Lesions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Overview of Cytological Dynamics of Periodontal Ligament Inflammatory Lesions","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["202","210","243","256","257","298","375"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-07"},"publish_date":"2018-03-07","publish_status":"0","recid":"2685","relation_version_is_last":true,"title":["Overview of Cytological Dynamics of Periodontal Ligament Inflammatory Lesions"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:59:33.699746+00:00"}