{"created":"2023-06-19T07:39:03.117516+00:00","id":2708,"links":{},"metadata":{"_buckets":{"deposit":"83679937-cd15-4c24-9c83-ff4f9d6fdd20"},"_deposit":{"created_by":3,"id":"2708","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2708"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002708","sets":["178:204","193:207:392","193:208:256","193:208:298","193:232:299","193:233:257","193:234:384","193:236:391","193:242:243"]},"author_link":["4032","4037","4034","4031","4036","4030","4033","4035"],"item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"焼結ルチル二酸化チタン上の骨芽細胞様細胞の増殖およびアルカリホスファターゼ活性"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"42","bibliographicPageStart":"37","bibliographicVolumeNumber":"26","bibliographic_titles":[{},{"bibliographic_title":"Journal of Hard Tissue Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of this study is creation of biomaterials from titanium dioxide (TiO2). This TiO2 has known for photocatalysis and osteogenesis. For the purpose of applying this function to orthodontic brackets and coating materials for implant, the relationship between surface of sintered and cell proliferation were examined. In addition, crystal structure and the surface property of sintering TiO2 were investigated. TiO2 were sintered at 1300°C for use as samples. We examined surface roughness, x-ray diffraction and scanning electron microscopy to make observations of the surface properties and texture. Moreover, mouse osteoblast-like cell line, MC3T3-E1 was cultured on sintered TiO2 in order to evaluate the cell proliferation and ALP. For the samples sintered at 1300°C, the crystalline phase of rutile-type TiO2 was confirmed.5000-fold magnified SEM\nimages of the surface of the unsintered samples, needle-like TiO2 crystals were pressure welded and showed mutual overlap, with pores occurring among the crystals. Sintering at 1300°C produced numerous small pores. Rutile TiO2 as a starting material was sintered at 1300°C and subjected to a cell culture experiment in which MC3T3-E1 cells were cultured on the sample, followed by viable cell counting and cell morphology observation\non days 7, 14, 21, and 28 of culture. In the test of cell proliferation, sintered at 1300°C samples was found to remarkable cell proliferation even after time had passed. ALP activity of cells on 1300°C TiO2 sample, the values were 110% and 126% on days 14 and 28 of culture, respectively. These changes were calculated using polystyrene dish as the reference condition. Thus, TiO2 sintered at 1300°C showed good compatibility and increase in the ALP activity in MC3T3-E1 cells.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Hard Tissue Regenerative Biology (硬組織再生生物学会)"}]},"item_10001_relation_12":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130005188394","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.2485/jhtb.26.37"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.26.37","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Jstage"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.26.37","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_24":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2017380838","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 by The Hard Tissue Biology Network Association(JHTBNet) "}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11074332","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-7649","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YOKOI, YUKIKO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UOZUMI, TOMOKO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUDA, SAEKA"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMANISHI, TOHRU"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TORIYA, JIN"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHOMURA, MASAHITO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OKAFUJI, NORIMASA"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OSUGA, NAOTO"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-07"}],"displaytype":"detail","filename":"2017-ja-017.pdf","filesize":[{"value":"5.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2708/files/2017-ja-017.pdf"},"version_id":"ddb6ea72-96e8-404d-a0ba-5e762cd3b5f1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"X線回折","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"歯科材料","subitem_subject_scheme":"Other"},{"subitem_subject":"表面特性","subitem_subject_scheme":"Other"},{"subitem_subject":"3T3細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞培養技術","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞増殖","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞形","subitem_subject_scheme":"Other"},{"subitem_subject":"走査型電気化学顕微鏡検査法","subitem_subject_scheme":"Other"},{"subitem_subject":"Titanium dioxide (TiO2)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biomaterials","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alkaline phosphatase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Polystyrenes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Titanium","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Proliferation and Alkaline Phosphatase Activity of Osteoblast-like Cells on the Sintered Rutile Titanium Dioxide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Proliferation and Alkaline Phosphatase Activity of Osteoblast-like Cells on the Sintered Rutile Titanium Dioxide","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["204","243","256","257","298","299","384","391","392"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-07"},"publish_date":"2018-03-07","publish_status":"0","recid":"2708","relation_version_is_last":true,"title":["Proliferation and Alkaline Phosphatase Activity of Osteoblast-like Cells on the Sintered Rutile Titanium Dioxide"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:58:45.202087+00:00"}