{"created":"2023-06-19T07:39:05.285469+00:00","id":2745,"links":{},"metadata":{"_buckets":{"deposit":"e6495268-89c3-4b7a-90b1-b46fa5735c13"},"_deposit":{"created_by":3,"id":"2745","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2745"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002745","sets":["178:441","193:194:195","193:242:357"]},"author_link":["4203","4204"],"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"e24120","bibliographicVolumeNumber":"5","bibliographic_titles":[{},{"bibliographic_title":"PeerJ.","bibliographic_titleLang":"en"}]}]},"item_7_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Previously, we revealed that several kampo medicines used for patients with excess and/or medium patterns (kakkonto (TJ-1), shosaikoto (TJ-9), hangeshashinto (TJ-14), and orento (TJ-120)) reduced prostaglandin (PG)E2 levels using LPS-treated human gingival fibroblasts (HGFs). Recently, we examined other kampo medicines used for patients with the deficiency pattern [bakumondoto (TJ-29), shinbuto (TJ-30), ninjinto (TJ-32), and hochuekkito (TJ-41)] and the herbs comprising shinbuto and ninjinto using the same experimental model. Shinbuto and ninjinto concentration-dependently reduced LPS-induced PGE2 production by HGFs, whereas hochuekkito weakly reduced and bakumondoto did not reduce PGE2 production. Shinbuto and ninjinto did not alter cyclooxygenase (COX) activity or the expression of molecules involved in the arachidonic acid cascade. Therefore, we next examined which herbs compromising shinbuto and ninjinto reduce LPS-induced PGE2 production. Among these herbs, shokyo (Zingiberis Rhizoma) and kankyo (Zingiberis Processum Rhizoma) strongly and concentration-dependently decreased LPS-induced PGE2 production. However, both shokyo and kankyo increased the expression of cytosolic phospholipase (cPL)A2 but did not affect annexin1 or COX-2 expression. These results suggest that shokyo and kankyo suppress cPLA2 activity. We demonstrated that kampo medicines suppress inflammatory responses in patients with the deficiency pattern, and in those with excess or medium patterns. Moreover, kampo medicines that contain shokyo or kankyo are considered to be effective for the treatment of inflammatory diseases.","subitem_description_type":"Abstract"}]},"item_7_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Corte Madera, CA : PeerJ Inc."}]},"item_7_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info.doi/10.7717/peerj.4120."}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.7717/peerj.4120","subitem_relation_type_select":"DOI"}}]},"item_7_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_7_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PubMed Central® (PMC)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713626/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"Peer J"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://peerj.com/articles/4120/","subitem_relation_type_select":"URI"}}]},"item_7_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2017 Ara and Sogawa"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2167-8359 ","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ara, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"4203","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sogawa, Norio"}],"nameIdentifiers":[{"nameIdentifier":"4204","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-21"}],"displaytype":"detail","filename":"2017-ja-005.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2745/files/2017-ja-005.pdf"},"version_id":"0c6062b1-8044-4dc2-a9ed-850dad642c4b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anti-inflammatory effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Arachidonic acid cascade","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Herb","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human gingival fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kampo medicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kankyo","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prostaglandin E2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Shokyo","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of shinbuto and ninjinto on prostaglandin E2 production in lipopolysaccharide-treated human gingival fibroblasts.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of shinbuto and ninjinto on prostaglandin E2 production in lipopolysaccharide-treated human gingival fibroblasts.","subitem_title_language":"en"}]},"item_type_id":"7","owner":"3","path":["195","357","441"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-15"},"publish_date":"2018-11-15","publish_status":"0","recid":"2745","relation_version_is_last":true,"title":["Effects of shinbuto and ninjinto on prostaglandin E2 production in lipopolysaccharide-treated human gingival fibroblasts."],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:57:34.079999+00:00"}