{"created":"2023-06-19T07:39:07.437079+00:00","id":2782,"links":{},"metadata":{"_buckets":{"deposit":"a3573e05-58ca-48cd-a886-70f95b426dcd"},"_deposit":{"created_by":3,"id":"2782","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2782"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002782","sets":["178:204","193:201:202","193:206:210","193:208:256","193:232:299","193:233:257","193:233:300","193:242:243"]},"author_link":["4551","4549","4548","4546","4552","4550","4547"],"item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウスにおける実験的根尖部炎症病変の確立"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"520","bibliographicPageStart":"517","bibliographicVolumeNumber":"22","bibliographic_titles":[{},{"bibliographic_title":"Journal of Hard Tissue Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract: Although studies on the formation of apical periodontitis have somehow been carried out but detailed cellular dynamics remain unclear. We recently established an experiment that could easily be performed using ddY mice. First, under general anesthesia using isoflurane inhalation, the coronal portion of the maxillary first molar was penetrated using a round bur and drill with water irrigation causing pulp exposure until the root apex. Micro computed tomography (R_mCT) was taken over time during observation. Four weeks later, R_mCT confirmed the presence of a radiolucent image at the apex of the tooth, which was then removed for histological examination. The results showed that granulation tissue with fibrosis had gradually formed at the periphery of the abscess. The present method confirmed the effectiveness of the experimental mode to exmine the formation of chronic inflammatory lesions at the root apex.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Hard Tissue Regenerative Biology (硬組織再生生物学会)"}]},"item_10001_relation_12":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130004480626","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.2485/jhtb.22.517"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.22.517","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Jstage"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.22.517","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_24":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2015046938","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 by The Hard Tissue Biology Network Association(JHTBNet) "}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11074332","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-7649","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_25":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_text_value":"根尖部炎症病変のマウスモデルを作製した。マウスをイソフラン吸入により麻酔し、上顎第1大臼歯の歯冠部をラウンドバーにより貫通させた後、水の灌注により穴をあけて根尖まで歯髄を露出させた。処置の4週間後、根尖部にX線透過性部位が存在することが、マイクロコンピュータートモグラフィーにより確認された。この部位について組織学的検査を行った結果、線維増生を示す肉芽組織が膿瘍の周辺に徐々に形成されることが明らかになった。以上より、本モデルは根尖部の慢性炎症病変の形成を調べる上で有用であることが示された。"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Osuga, Naoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Saeka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shoumura, Masahito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriyama, Keita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokoi, Yukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Toshiyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-20"}],"displaytype":"detail","filename":"2018-ja-001.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2782/files/2018-ja-001.pdf"},"version_id":"bb1867c5-8c62-4665-8865-e02abec51194"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔粘膜下線維症","subitem_subject_scheme":"Other"},{"subitem_subject":"根尖性歯周炎","subitem_subject_scheme":"Other"},{"subitem_subject":"根尖部歯周組織","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"大臼歯","subitem_subject_scheme":"Other"},{"subitem_subject":"肉芽組織","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"CD31抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"歯根尖","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロX線CT","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammatory apical periodontitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Experimental model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Micro-CT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Histopathology","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Establishment of Experimental Periapical Inflammatory Lesions in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Establishment of Experimental Periapical Inflammatory Lesions in Mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["202","204","210","243","256","257","299","300"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-20"},"publish_date":"2019-02-20","publish_status":"0","recid":"2782","relation_version_is_last":true,"title":["Establishment of Experimental Periapical Inflammatory Lesions in Mice"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:56:29.769360+00:00"}