{"created":"2023-06-19T07:39:07.646815+00:00","id":2785,"links":{},"metadata":{"_buckets":{"deposit":"d198f6f0-253b-4f5b-b307-c631b3213c76"},"_deposit":{"created_by":3,"id":"2785","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2785"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002785","sets":["178:204","193:207:211","193:208:298","193:232:265","193:233:297"]},"author_link":["4572","4584","4576","4579","4573","4580","4585","4570","4581","4578","4583","4577","4574","4568","4582","4571","4569","4575"],"item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Transplanted Bone Marrow-derived Cell Migration into Periodontal Tissues and Cell Differentiation"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"305","bibliographicPageStart":"301","bibliographicVolumeNumber":"20","bibliographic_titles":[{},{"bibliographic_title":"Journal of Hard Tissue Biology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muraoka, Rina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsujigiwa, Hidetsugu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katase, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamamura., Ryo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomida, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okafuji, Norimasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagatsuka, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Toshiyuki"}],"nameIdentifiers":[{}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウスを用いて、歯周組織に歯科矯正学的メカニカルストレスを負荷することによって生じる牽引側および圧迫側歯根膜組織の変化について、熱ショックタンパクHSP70およびp-HSP70の発現を免疫組織化学的に検討した。HSP70は時間の経過と共に陽性反応が増強した。p-HSP70は、HSP70の発現より遅れて陽性反応の増強を示した。HSP70がホメオスタシスの維持や傷害を受けた細胞の修復、またそのリン酸化したp-HSP70として、牽引側歯根膜組織における骨芽細胞活性化による同部への骨添加傾向へのシフトが正常に行われるよう分子シャペロンとして働き、タンパク質のフォールディングなどの立体構造形成を助けていることが示唆された。","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Hard Tissue Regenerative Biology (硬組織再生生物学会)"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.2485/jhtb.20.301"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.20.301","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Jstage"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.20.301","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_24":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2012162424","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011 by The Hard Tissue Biology Network Association(JHTBNet) "}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11074332","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-7649","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_25":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_text_value":"Heat shock proteins (HSPs) are induced by not only the heat shock but also the mechanical stress. Orthodontic tooth movement induced mechanical stress in the related periodontal ligament. It is important to examine the inununohistochemical profile change of the Heat shock proteins (HSPs) in the periodontal ligament cells after receiving the mechanical stress for orthodontic treatment. Therefore, we examined the HSPs in the periodontal ligament cells of ddY mice using the Waldo method. In the control group, periodontal ligament was observed as physiological anangement, and which reacted weakly to HSP27 and HSP70. In the experimental group the extension site of the periodontal ligament cells and the expansion of the blood vessel occuned in the traction side. These tissues were strongly reacted to HSP27 and HSP70. The findings suggeste that the HSPsexpression work as the mechanism of maintenance of homeostasis in the periodontal tissues."}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村岡, 理奈"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻極, 秀次"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中野, 敬介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"片瀬, 直樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"玉村, 亮"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"富田, 美穂子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡藤, 範正"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長塚, 仁"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川上, 敏行"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-20"}],"displaytype":"detail","filename":"2018-ja-006.pdf","filesize":[{"value":"268.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2785/files/2018-ja-006.pdf"},"version_id":"9ab08d87-b796-44d6-a898-49368da672da"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨髄移植","subitem_subject_scheme":"Other"},{"subitem_subject":"骨髄細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞運動","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞分化","subitem_subject_scheme":"Other"},{"subitem_subject":"歯根膜","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周組織","subitem_subject_scheme":"Other"},{"subitem_subject":"線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"破骨細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスジェニックマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"CD34抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"C57BLマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"Green Fluorescent Proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"Tartrate-Resistant Acid Phosphatase","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"},{"subitem_subject":"メス","subitem_subject_scheme":"Other"},{"subitem_subject":"歯学\\n","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone marrow-derived cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Green fluorescent protein (GFP)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontal tissues","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoclasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Macrophages","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"移植骨髄由来細胞の歯周組織への移動と細胞分化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"移植骨髄由来細胞の歯周組織への移動と細胞分化"}]},"item_type_id":"10001","owner":"3","path":["204","211","265","297","298"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-20"},"publish_date":"2019-02-20","publish_status":"0","recid":"2785","relation_version_is_last":true,"title":["移植骨髄由来細胞の歯周組織への移動と細胞分化"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:56:26.116115+00:00"}