{"created":"2023-06-19T07:39:07.714939+00:00","id":2786,"links":{},"metadata":{"_buckets":{"deposit":"25d55812-83f7-4241-b670-766447b51d12"},"_deposit":{"created_by":3,"id":"2786","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2786"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002786","sets":["178:204","193:201:202","193:208:298","193:232:265","193:233:297"]},"author_link":["4599","4590","4591","4586","4593","4595","4597","4588","4587","4592","4589","4594","4598","4596"],"item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A Consideration on the Role of HSP70 Appearing in the Periodontal Tissues due to Experimental Orthodontic Force"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"281","bibliographicPageStart":"275","bibliographicVolumeNumber":"20","bibliographic_titles":[{},{"bibliographic_title":"Journal of Hard Tissue Biology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muraoka, Rina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomoda, Maki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okafuji, Norimasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Toshiyuki"}],"nameIdentifiers":[{}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"実験的歯科矯正力によりマウス歯根膜組織に誘導されるHSP70 とp-HSP70 の初期における発現状況の変化を免疫組織化学的に検討した。その結果、対照群歯根膜線維芽細胞はその歯根膜の全周にわたるHSP70 とp-HSP70 の活性が低い状態で保たれていた。実験群では、HSP70 は時間の経過とともに陽性反応が増強していた。p-HSP70は、HSP70の発現より若干遅れて陽性反応の増強を示して\nいた。これらの実験結果はHSP70がホメオスタシスの維持や傷害を受けた細胞の修復、またそのリン酸化したp-HSP70として、牽引側歯根膜組織における骨芽細胞活性化による同部への骨添加傾向へのシフトが正常に行われるよう分子シャペロンとして働いていることを示唆した。","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Hard Tissue Regenerative Biology (硬組織再生生物学会)"}]},"item_10001_relation_12":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130004848367","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.2485/jhtb.20.275"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.20.275","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Jstage"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.20.275","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_24":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2012162420","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011 by The Hard Tissue Biology Network Association(JHTBNet) "}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11074332","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-7649","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_25":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_text_value":"We examined immunohistochemical expressions of HSP70 and p-HSP70 in the orthodontic periodontal tissues. In the control group, the HSP70 and p-HSP70 expression was observed in the periodontal ligament fibroblasts and that was kept in low levels. In the experimental group, the strong expression of HSP70 was detected according to over time. However, p-HSP70 expression was a bit delayed. The data suggests thatHSP70 has been closely involved in the repair of tissue to maintain homeostasis of the periodontal tissues by the activation of periodontal ligament fibroblasts. Farthermore, the data also suggests that HSP70 act as a molecular chaperone of osteogenesis through an activation of osteoblasts."}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村岡, 理奈"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中野, 敬介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松田, 浩和"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"共田, 真紀"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡藤, 範正"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 一尋"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川上, 敏行"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-20"}],"displaytype":"detail","filename":"2018-ja-005.pdf","filesize":[{"value":"200.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2786/files/2018-ja-005.pdf"},"version_id":"05a5bdda-b460-4fe8-8357-ae85cf785108"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝子発現調節","subitem_subject_scheme":"Other"},{"subitem_subject":"メカニカルストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"歯科矯正治療","subitem_subject_scheme":"Other"},{"subitem_subject":"歯根膜","subitem_subject_scheme":"Other"},{"subitem_subject":"線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"リン酸化","subitem_subject_scheme":"Other"},{"subitem_subject":"HSP70 Heat-Shock Proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"分子シャペロン","subitem_subject_scheme":"Other"},{"subitem_subject":"歯科矯正力","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"},{"subitem_subject":"オス","subitem_subject_scheme":"Other"},{"subitem_subject":"歯学","subitem_subject_scheme":"Other"},{"subitem_subject":"Heat Shock Protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HSP70","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontal tissues","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Orthodontic mechanical stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Orthodontic tooth movement","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"実験的歯科矯正力により歯根膜組織に発現するHSP70の役割に関する一考察","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"実験的歯科矯正力により歯根膜組織に発現するHSP70の役割に関する一考察"}]},"item_type_id":"10001","owner":"3","path":["202","204","265","297","298"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-20"},"publish_date":"2019-02-20","publish_status":"0","recid":"2786","relation_version_is_last":true,"title":["実験的歯科矯正力により歯根膜組織に発現するHSP70の役割に関する一考察"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:56:24.083329+00:00"}