{"created":"2023-06-19T07:39:08.046799+00:00","id":2791,"links":{},"metadata":{"_buckets":{"deposit":"68117390-f02c-4420-b3e0-d08de9e19dcd"},"_deposit":{"created_by":3,"id":"2791","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2791"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002791","sets":["178:204","193:208:298"]},"author_link":["4627"],"item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"実験的ウサギ下顎欠損のrhBMP-2とアテロコラーゲンゲルによる再構築　in vivo μCTによる観察と組織学的検索"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"79","bibliographicPageStart":"78","bibliographicVolumeNumber":"14","bibliographic_titles":[{},{"bibliographic_title":"Journal of Hard Tissue Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A rabbit experimental mandibular defect was reconstructed with rhBMP-2 and atelocollagen gel, and examined using μCT (R_mCT, Rigaku Mechatronics, Tokyo) in vivo and histological techniques. Using eight rabbits, we made an experimental mandibular defect and filled it with 1% atelocollagen gel including rhBMP-2 10ìg (Astellas Pharma Inc.). In μCT observation, the density was slightly elevated at the bone marrow side at one week, and the phenomenon gradually expanded during the course of this experiment. Histologically, mesenchymal cell proliferation and immature bone formation occurred at one week, and mature bone gradually increased and filled in at four weeks. ","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Hard Tissue Regenerative Biology (硬組織再生生物学会)"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.2485/jhtb.14.78"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.14.78","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版) "}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Jstage"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2485/jhtb.14.78","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_24":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2007049464","subitem_relation_type_select":"ICHUSHI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2005 by The Hard Tissue Biology Network Association(JHTBNet) "}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11074332","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-7649","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_25":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_text_value":"ウサギ8羽の下顎を実験的に欠損させ、欠損部位を組換えヒト骨形態発生蛋白を含む1%アテロコラーゲンゲルで満たした。1週間後にこの部位をμCTで観察したところ、密度が骨髄側で軽度上昇していた。この現象は経時的に広がっていくことが示された。組織学的検索では、1週間後に間葉細胞の増殖と未熟骨細胞の形成が認められ、4週間後には成熟細胞が徐々に増加して下顎欠損部位を満たしていた。"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okafuji, Norimasa"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-20"}],"displaytype":"detail","filename":"2018-ja-010.pdf","filesize":[{"value":"179.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2791/files/2018-ja-010.pdf"},"version_id":"462f9b8a-9011-4322-85a0-1d4f0ce65eb8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Collagen; Glycolates","subitem_subject_scheme":"Other"},{"subitem_subject":"下顎疾患(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"下顎再建術","subitem_subject_scheme":"Other"},{"subitem_subject":"異物巨細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"骨髄","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"X線CT","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"Poly(lactic Acid)","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞増殖","subitem_subject_scheme":"Other"},{"subitem_subject":"骨形成因子-2","subitem_subject_scheme":"Other"},{"subitem_subject":"Atelocollagen","subitem_subject_scheme":"Other"},{"subitem_subject":"Glycolic Acid","subitem_subject_scheme":"Other"},{"subitem_subject":"rhBMP-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"atelocollagen gel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone reconstruction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"μ CT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rabbit","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reconstruction of Rabbit Experimental Mandibular Defect with rhBMP-2 and Atelocollagen Gel: μCT Observation in Vivo and Histological Examination","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reconstruction of Rabbit Experimental Mandibular Defect with rhBMP-2 and Atelocollagen Gel: μCT Observation in Vivo and Histological Examination","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["204","298"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-20"},"publish_date":"2019-02-20","publish_status":"0","recid":"2791","relation_version_is_last":true,"title":["Reconstruction of Rabbit Experimental Mandibular Defect with rhBMP-2 and Atelocollagen Gel: μCT Observation in Vivo and Histological Examination"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:56:13.008627+00:00"}