{"created":"2023-06-19T07:39:09.468337+00:00","id":2827,"links":{},"metadata":{"_buckets":{"deposit":"519a9f2a-4be2-435d-a054-73733b4802b3"},"_deposit":{"created_by":3,"id":"2827","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2827"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002827","sets":["178:480","193:201:202","193:206:210","193:207:211"]},"author_link":["4711","4709","4708","4712","4710","4713"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"184","bibliographicPageStart":"180-184","bibliographicVolumeNumber":"15","bibliographic_titles":[{},{"bibliographic_title":"European journal of medical research","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown. Case report:This paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and there has been no follow-up clinical record of recurrence 5 years after primary treatment. Histopathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT. Immunohistochemical evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch1, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap. No immunoreactivity was detected for Notch2 and Jagged2. Conclusions:Present findings suggest that Notch receptors and their ligands play differential roles in the cytodifferentiation of SOT.\n","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"I. Holzapfel(BioMed Central)"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/20554499","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.1186/2047-783X-15-4-180"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/2047-783X-15-4-180","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"BioMed Central"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/2047-783X-15-4-180","subitem_relation_type_select":"DOI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"PubMed Central"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401003/","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©  I. Holzapfel Publishers 2010. licensed under the Creative Commons Attribution License 4.0. (https://creativecommons.org/licenses/by/4.0/legalcode)"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11331989","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2047-783X ","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Siar, CH"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ng, KH"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomida, M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagatsuka  H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami  T"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-15"}],"displaytype":"detail","filename":"2019-JA-002.pdf","filesize":[{"value":"5.7 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2827/files/2019-JA-002.pdf"},"version_id":"118a049b-6df5-47c3-9c58-9501d2fe8742"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"solitary odontogenic tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Notch signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytodifferentiation\\n","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SQUAMOUS ODONTOGENIC TUMOR OF THE MANDIBLE: A CASE REPORT DEMONSTRATING IMMUNOEXPRESSION OF NOTCH1, 3, 4, JAGGED1 AND DELTA1","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SQUAMOUS ODONTOGENIC TUMOR OF THE MANDIBLE: A CASE REPORT DEMONSTRATING IMMUNOEXPRESSION OF NOTCH1, 3, 4, JAGGED1 AND DELTA1","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["202","210","211","480"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-15"},"publish_date":"2019-05-15","publish_status":"0","recid":"2827","relation_version_is_last":true,"title":["SQUAMOUS ODONTOGENIC TUMOR OF THE MANDIBLE: A CASE REPORT DEMONSTRATING IMMUNOEXPRESSION OF NOTCH1, 3, 4, JAGGED1 AND DELTA1"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:54:49.953137+00:00"}