{"created":"2023-06-19T07:39:09.515127+00:00","id":2828,"links":{},"metadata":{"_buckets":{"deposit":"94f46318-7b53-44bb-b0b7-9cfff19a6db3"},"_deposit":{"created_by":3,"id":"2828","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2828"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002828","sets":["178:438","193:201:202"]},"author_link":["4714","4716","4717","4718","4719","4720","4715"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"1973","bibliographicVolumeNumber":"20","bibliographic_titles":[{},{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Histopathological findings of oral neoplasm cell differentiation and metaplasia suggest that tumor cells induce their own dedifferentiation and re-differentiation and may lead to the formation of tumor-specific histological features. Notch signaling is involved in the maintenance of tissue stem cell nature and regulation of differentiation and is responsible for the cytological regulation of cell fate, morphogenesis, and/or development. In our previous study, immunohistochemistry was used to examine Notch expression using cases of odontogenic tumors and pleomorphic adenoma as oral neoplasms. According to our results, Notch signaling was specifically associated with tumor cell differentiation and metaplastic cells of developmental tissues. Notch signaling was involved in the differentiation of the ductal epithelial cells of salivary gland tumors and ameloblast-like cells of odontogenic tumors. However, Notch signaling was also involved in squamous metaplasia, irrespective of the type of developmental tissue. In odontogenic tumors, Notch signaling was involved in epithelial–mesenchymal interactions and may be related to tumor development and tumorigenesis. This signaling may also be associated with the malignant transformation of ameloblastomas. Overall, Notch signaling appears to play a major role in the formation of the characteristic cellular composition and histological features of oral neoplasms, and this involvement has been reviewed here.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI AG"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.3390/ijms20081973"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms20081973","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"MDPI"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms20081973","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). (http://creativecommons.org/licenses/by/4.0]/)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1422-0067","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Keisuke, Nakano"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiyofumi, Takabatake"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hotaka, Kawai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saori, Yoshida"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatsuhiko, Maeda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toshiyuki, Kawakami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hitoshi, Nagatsuka 1"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-15"}],"displaytype":"detail","filename":"2019-JA-004.pdf","filesize":[{"value":"6.7 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2828/files/2019-JA-004.pdf"},"version_id":"4bb6edc5-5a2e-4991-ae86-b8380511f63c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"odontogenic tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pleomorphic adenoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"notch signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epithelial-mesenchymal interaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"malignant transformation ","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Notch signaling acts on cell differentiation and acquisition of tumor-specific character of oral neoplasms","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Notch signaling acts on cell differentiation and acquisition of tumor-specific character of oral neoplasms","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["202","438"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-15"},"publish_date":"2019-05-15","publish_status":"0","recid":"2828","relation_version_is_last":true,"title":["Notch signaling acts on cell differentiation and acquisition of tumor-specific character of oral neoplasms"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T07:54:54.300493+00:00"}