{"created":"2023-06-19T07:39:09.562069+00:00","id":2829,"links":{},"metadata":{"_buckets":{"deposit":"7543d5d0-6432-4556-8af4-2658aeefb61a"},"_deposit":{"created_by":3,"id":"2829","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2829"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002829","sets":["178:481","193:201:202"]},"author_link":["4735","4728","4722","4724","4726","4732","4729","4733","4736","4727","4725","4723","4734","4730","4731","4721"],"item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"皮下組織および筋間組織におけるBMP‐2促進骨誘導によるヒト酸不溶性象牙質"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1378","bibliographicPageEnd":"441","bibliographicPageStart":"438-441","bibliographicVolumeNumber":"118","bibliographic_titles":[{},{"bibliographic_title":"Journal of the ceramic society of JAPAN","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村田, 勝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河合, 達志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川上, 敏行"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"赤澤, 敏之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田崎, 純一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 勝敏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"草野, 薫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"有末, 真"}],"nameIdentifiers":[{}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dentin matrix is well known as the most insoluble collagen in human body. We already confirmed the osteoinductive property by granules of human demineralized dentin matrix (DDM) histologically. Human DDM granules and human demineralized root-dentin (DRD) mass were prepared from adult vital teeth. The hard tissue induction by DDM alone or DRD alone was estimated at 4 weeks after implantation. The DDM alone induced bone and cartilage independently. In addition, the bioassay by recombinant human BMP-2 (5.0 .MU.g)/DDM or BMP-2 (5.0 .MU.g)/DRD was estimated in mouse subcutaneous or intramuscular tissues, respectively. Histological examination showed that the BMP-2/DDM induced bone and marrow, and the DDM granules were partially absorbed by new bone. The morphometric analysis demonstrated that the BMP-2/DDM showed 36.3% in the volume of bone and marrow, while the DDM alone showed 1.3% at 4 weeks. Moreover, the BMP-2/DRD also induced active bone formation on the root surface and in the pulp cavity. These results indicate that BMP-2 significantly accelerated bone formation in decalcified dentin implants. Human recycled DDM and DRD might be effective materials as osteoinductive collagenous carriers of BMP-2 for bone engineering. (Author abst.)","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"公益社団法人 日本セラミックス協会"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.2109/jcersj2.118.438"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2109/jcersj2.118.438","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"J-Stage"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2109/jcersj2.118.438","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2010 The Ceramic Society of Japan. licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.(https://creativecommons.org/licenses/by-nd/4.0/)"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12229489","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1882-0743","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_25":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_text_value":"人体において象牙質はほとんど不溶性コラーゲンであると知られている。ヒト脱ミネラル化歯質(DDM)の顆粒による骨誘導性を組織学的に確認した。ヒトDDM顆粒とヒト脱ミネラル化歯根象牙質(DRD)を成人の活歯から作製した。移植して4週間後のDDM単独またはDRD単独で誘導された硬組織を評価した。また,組換ヒトBMP‐2(5.0μg)/DDMまたはBMP‐2(5.0μg)/DRDによるバイオアッセイをそれぞれマウス皮下組織または筋間組織において評価した。組織学的評価の結果,BMP‐2/DDM誘導骨および髄質,およびDDM顆粒は新骨によって部分的に吸収されることが分かった。形態的分析では,4週間後の骨と髄質の体積の36.3%はBMP‐2/DDMであったが,DDM単独では1.3%であった。BMP‐2/DDMは歯根面や歯根管でも活性な骨形成を誘導した。これらの結果から,BMP‐2は脱石灰象牙質移植において骨形成を著しく促進することが示唆された。ヒト再生DDMおよびDRDは骨工学におけるBMP‐2の骨誘導コラーゲン担体として有効な材料である。(翻訳著者抄録)"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MURATA, Masaru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWAI, Tatsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWAKAMI, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AKAZAWA, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAZAKI, Junichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ITO, Katsutoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUSANO, Kaoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ARISUE, Makoto"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-15"}],"displaytype":"detail","filename":"2019-JA-003.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_8","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2829/files/2019-JA-003.pdf"},"version_id":"7812d211-0729-4981-8b57-2abbb5ef45c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"バイオセラミック","subitem_subject_scheme":"Other"},{"subitem_subject":"歯科用材料","subitem_subject_scheme":"Other"},{"subitem_subject":"象牙質","subitem_subject_scheme":"Other"},{"subitem_subject":"不溶性","subitem_subject_scheme":"Other"},{"subitem_subject":"コラーゲン","subitem_subject_scheme":"Other"},{"subitem_subject":"生体適合性","subitem_subject_scheme":"Other"},{"subitem_subject":"骨形成","subitem_subject_scheme":"Other"},{"subitem_subject":"除去","subitem_subject_scheme":"Other"},{"subitem_subject":"歯根","subitem_subject_scheme":"Other"},{"subitem_subject":"移植 動物","subitem_subject_scheme":"Other"},{"subitem_subject":"硬組織","subitem_subject_scheme":"Other"},{"subitem_subject":"骨形成因子","subitem_subject_scheme":"Other"},{"subitem_subject":"蛋白質","subitem_subject_scheme":"Other"},{"subitem_subject":"皮下組織","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオアッセイ","subitem_subject_scheme":"Other"},{"subitem_subject":"キャリア","subitem_subject_scheme":"Other"},{"subitem_subject":"骨誘導","subitem_subject_scheme":"Other"},{"subitem_subject":"骨誘導性","subitem_subject_scheme":"Other"},{"subitem_subject":"脱ミネラル","subitem_subject_scheme":"Other"},{"subitem_subject":"BMP‐2","subitem_subject_scheme":"Other"},{"subitem_subject":"担体","subitem_subject_scheme":"Other"},{"subitem_subject":"Human","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dentin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Demineralization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone Induction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BMP-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["202","481"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-15"},"publish_date":"2019-05-15","publish_status":"0","recid":"2829","relation_version_is_last":true,"title":["Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:54:48.893391+00:00"}