{"created":"2023-06-19T07:37:16.314205+00:00","id":283,"links":{},"metadata":{"_buckets":{"deposit":"25e30a7c-b89f-42b5-9a0a-91027fac7d6e"},"_deposit":{"created_by":3,"id":"283","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"283"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000283","sets":["1:12:61"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Effect of Sodium Arsenite on Drug-Metabolizing Enzymes in Rat Liver"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1981-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"67","bibliographicPageStart":"64","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of sodium arsenite on drug-metabolizing enzymes in rat liver was studied in vivo and in vitro. In the in vitro study, aminopyrine demethylase, hexobarbital oxidase and aniline hydroxylase were all inhibited when sodium arsenite was added to the incubation mixtures. In the in vivo study, when rats were ingested sodium arsenite in their drinking water for a month, it was observed that the quantity of drinking water was decreased against the increase of arsenic concentration. The maximam intake of arsenic from drinking water was 9mg/kg/day. Body weight and liver-body weight ratio were rather increased in low arsenic concentration, but they were decreased in high concentration. The three of drug-metabolizing enzymes were inhibited as well. The inhibition was stronger in vivo under the same arsenic concentration.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"倉橋, 寿"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-23"}],"displaytype":"detail","filename":"matsumoto_shigaku_07-01-05.pdf","filesize":[{"value":"198.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_07-01-05.pdf","url":"https://mdu.repo.nii.ac.jp/record/283/files/matsumoto_shigaku_07-01-05.pdf"},"version_id":"3ebda8d7-c864-46e0-85f0-0347d7f9dda4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"砒素のラット肝薬物代謝酵素に対する影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"砒素のラット肝薬物代謝酵素に対する影響"}]},"item_type_id":"2","owner":"3","path":["61"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-23"},"publish_date":"2012-05-23","publish_status":"0","recid":"283","relation_version_is_last":true,"title":["砒素のラット肝薬物代謝酵素に対する影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:41:39.036108+00:00"}