{"created":"2023-06-19T07:39:11.652456+00:00","id":2874,"links":{},"metadata":{"_buckets":{"deposit":"bdd406ab-7f68-40ce-a46c-dce29bedae60"},"_deposit":{"created_by":3,"id":"2874","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2874"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00002874","sets":["178:438","193:194:421","193:205:412","193:233:247","193:234:422"]},"author_link":["5012","5007","5005","5004","5006","5008","5011","5009","5003","5010"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"E4113","bibliographicVolumeNumber":"19","bibliographic_titles":[{},{"bibliographic_title":"International journal of molecular sciences.","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hossain, MZ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安藤, 宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"海野, 俊平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"増田, 裕次"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北川, 純一"}],"nameIdentifiers":[{}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The larynx and associated laryngopharyngeal regions are innervated by the superior laryngeal nerve (SLN) and are highly reflexogenic. Transient receptor potential (TRP) channels have  recently been detected in SLN innervated regions; however, their involvement in the swallowing reflex has not been fully elucidated. Here, we explore the contribution of two TRP channels, TRPV1 and TRPM8, located in SLN-innervated regions to the swallowing reflex. Immunohistochemistry identified TRPV1 and TRPM8 on cell bodies of SLN afferents located in the nodose-petrosal-jugular ganglionic complex. The majority of TRPV1 and TRPM8 immunoreactivity was located on unmyelinated neurons. Topical application of different concentrations of TRPV1 and TRPM8 agonists modulated SLN activity. Application of the agonists evoked a significantly greater number of swallowing reflexes compared with the number evoked by distilled water. The intervalbetween the reflexes evoked by the agonists was shorter than that produced by distilled water. Prior topical application of respective TRPV1 or TRPM8 antagonists significantly reduced the number of agonist-evoked reflexes. The findings suggest that the activation of TRPV1 and TRPM8 channels present in the swallowing-related regions can facilitate the evoking of swallowing reflex. Targeting the TRP channels could be a potential therapeutic strategy for the management of dysphagia.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"30567389","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"info:doi/10.3390/ijms19124113."}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms19124113","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PubMed Central"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321618/","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 by the authors."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1422-0067","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hossain, MZ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ando, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Unno, Shumpei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuda, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitagawa, Junichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-12-18"}],"displaytype":"detail","filename":"2019-JA-009.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/2874/files/2019-JA-009.pdf"},"version_id":"7ca4b0d0-db6d-4534-b0c6-43cdd63ff592"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TRPV1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TRPM8","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Superior laryngeal nerve","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Swallowing reflex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dysphagia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activation of TRPV1 and TRPM8 Channels in the Larynx and Associated Laryngopharyngeal Regions Facilitates the Swallowing Reflex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation of TRPV1 and TRPM8 Channels in the Larynx and Associated Laryngopharyngeal Regions Facilitates the Swallowing Reflex","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["247","412","421","422","438"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-18"},"publish_date":"2019-12-18","publish_status":"0","recid":"2874","relation_version_is_last":true,"title":["Activation of TRPV1 and TRPM8 Channels in the Larynx and Associated Laryngopharyngeal Regions Facilitates the Swallowing Reflex"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T07:53:39.554468+00:00"}