@article{oai:mdu.repo.nii.ac.jp:00002923,
 author = {OGAWA, SAORI and TANIYAMA, KIICHI and UEDA, KEISUKE and SHIBUTANI, TOHRU and 小川, さおり and 谷山, 貴一 and 上田, 敬介 and 澁谷, 徹},
 issue = {1},
 journal = {松本歯学, Journal of the Matsumoto Dental University Society},
 month = {Jul},
 note = {application/pdf, Progressive muscular dystrophy (PMD) is a hereditary disease showing degeneration and necrosis of muscle fiber and progressive muscle weakness. PMD includes Duchenne and Becker types, in addition to limb–girdle and Fukuyama types. We report six cases of PMD (two cases of Duchenne type and four cases of Fukuyama type) treated since 2000 to 2019, in which general anesthesia was performed for intensive dental treatment.The serum level of creatine phosphokinase (CPK) was remarkably higher than normal level in every patients. No remarkable findings in chest x–ray and ECG were pointed.For patients with Duchenne type PMD,anesthesia was induced with propofol and nondepolarizing muscle relaxants,and maintained with nitrous oxide and propofol.For patients with Fukuyama type PMD, anesthesia was induced with sevoflurane in every patients and no muscle relaxant was used. Anesthesia was maintained with nitrous oxide in combination with sevoflurane in three cases, and it was maintained with nitrous oxide and propofol in another case.No remarkable cardiovascular and respiratory dysfunctions were pointed in every patients.The problems for the management of general anesthesia in patients with PMD are(1)circulatory failure due to myocardial damage,(2)respiratory failure due to respiratory dysfunction,(3)induction of malignant hyperthermia due to agents for general anesthesia, and(4) increased sensitivity and prolonged effects of muscle relaxants. In patients with Duchenne type PMD,volatile inhalation anesthetics were not used,which considered to be a risk factor for malignant hyperthermia.On the other hand, in patients with Fukuyama type PMD,we used sevoflurane since the incidence of malignant hyperthermia by volatile inhalation anesthetic will be low.},
 pages = {16--22},
 title = {General anesthetic management of six cases with progressive muscular dystrophy for dental treatment},
 volume = {46},
 year = {2020}
}