{"created":"2023-06-19T07:39:19.691134+00:00","id":3005,"links":{},"metadata":{"_buckets":{"deposit":"9e3924f9-bd42-4bce-ac61-1b8bab2cd78e"},"_deposit":{"created_by":3,"id":"3005","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3005"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00003005","sets":["170:542"]},"author_link":["5557","5553","5558","5560","5556","5555","5559","5554"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"口腔粘膜上皮における角質化細胞エンベロープ形成へのトランスグルタミナーゼと基質たんぱく質の寄与"}]},"item_10006_biblio_info_28":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"e12760","bibliographicVolumeNumber":"129","bibliographic_titles":[{},{"bibliographic_title":"European journal of oral sciences","bibliographic_titleLang":"en"}]}]},"item_10006_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Roy, Rita  Rani"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Katsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegwa, Hiromasa"}],"nameIdentifiers":[{}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-01-31"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"松本歯科大学"}],"subitem_degreegrantor_identifier":[{}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2021","subitem_description_type":"Other"}]},"item_10006_description_12":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_description":"甲第246号","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cornified envelope formation is crucial for the final differentiation of keratinized epithelium.However,the mechanisms of cornified envelope formation in the oral epithelium remain unclear.The aim of this study was to clarify the differences in the distribution and expression of cornified envelope related proteins and genes between keratinized and non-keratinized oral epithelia.We immunohistochemically investigated the distribution patterns of transglutaminase1(TG1),transglutaminase3(TG3),and their substrate proteins involucrin(IVL),loricrin(LOR),and small pro[1]line rich proteins(SPRs),in 19 keratinized and 14 non-keratinized oral epithelium samples.TG1 and TG3 mRNA levels were investigated in both types of epithelium by real time reverse transcription polymerase chain reaction(RT-PCR)using paraf[1]fin-embedded specimens.Data were analyzed to identify factors involved in cornified envelope formation.We demonstrate that 11 localization patterns show statistically significant differences between keratinized and non-keratinized oral epithelia.These factors clearly drove the separation of the two groups during cluster analysis.TG1 mRNA levels in keratinized oral epithelium were significantly higher than those in non-keratinized oral epithelium.In conclusion,the characteristic distribution of trans[1]glutaminases and their substrates and the mRNA levels of TG1 can regulate cornified envelope formation in keratinized oral epithelium, together with the contribution of TG3 first reported in this paper","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_22":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第246号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文（電子版）"}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Wiley Online Library"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/full/10.1111/eos.12760","subitem_relation_type_select":"URI"}}]},"item_10006_relation_23":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33501693","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 European Journal of Oral Sciences"}]},"item_10006_source_id_27":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1600-0722","subitem_source_identifier_type":"ISSN"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"内容の要旨および審査の結果の要旨","url":"https://mdu.repo.nii.ac.jp/record/3005/files/33602_A000282_shinsa-yoshi.pdf"},"version_id":"b9daaf10-34b2-4562-bd49-d3cf82aac7c3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-20"}],"displaytype":"detail","filename":"33602_A000282_honbun.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://mdu.repo.nii.ac.jp/record/3005/files/33602_A000282_honbun.pdf"},"version_id":"61e14378-1d53-4f8a-bf3a-e3980746b77d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cornified envelope","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"keratinized oral epithelium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-keratinized oral epithelium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"substrates","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transglutaminase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"3","path":["542"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-06-20"},"publish_date":"2022-06-20","publish_status":"0","recid":"3005","relation_version_is_last":true,"title":["Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T07:50:01.984128+00:00"}