{"created":"2023-06-19T07:37:17.475866+00:00","id":320,"links":{},"metadata":{"_buckets":{"deposit":"7734b2b5-5da0-4f01-8340-030509cf1cce"},"_deposit":{"created_by":3,"id":"320","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"320"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000320","sets":["1:13:63"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Binding of Arsenic to Erythrocytes of Rats in vivo and in vitro"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1982-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"55","bibliographicPageStart":"51","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In measuring the osmotic fragility of rat erythrocytes by centrifugation using coil planet centrifuge, it was found that arsenic trioxide given orally to rats caused a significant increase in the osmotic fragility. However, in vitro tests on the erythrocytes in which one ml of blood was incubated with arsenic trioxide equivalent to 2～500μg of arsenic at 37℃ for 1 hr, no significant changes were observed. Monomethylarsonic acid and dimethylarsinic acid, known as metabolites of inorganic arsenic, induced no significant changes in the osmotic fragility in vitro tests on erytherocytes. The arsenic concentration in erythrocytes was measured in the tests in vitro and in vivo using flameless atomic absorption spectrometry. When arsenic was given orally to rats, more than 90% of arsenic in whole blood was found in erythrocytes. However, in vitro tests, only 30.4～47.5% was detected on erythrocytes even after 6 hrs incubation. These results obtained in relation to arsenic concentration may explain the effect of the arsenic on the osmotic fragility of rat erythrocytes.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前橋, 浩"},{"creatorName":"山口, 由理子"},{"creatorName":"都筑, 新太郎"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-23"}],"displaytype":"detail","filename":"matsumoto_shigaku_08-01-05.pdf","filesize":[{"value":"271.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_08-01-05.pdf","url":"https://mdu.repo.nii.ac.jp/record/320/files/matsumoto_shigaku_08-01-05.pdf"},"version_id":"e2beffa4-2e90-4720-8295-77da80a8df29"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒ素化合物のラット赤血球への移行","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒ素化合物のラット赤血球への移行"}]},"item_type_id":"2","owner":"3","path":["63"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-23"},"publish_date":"2012-05-23","publish_status":"0","recid":"320","relation_version_is_last":true,"title":["ヒ素化合物のラット赤血球への移行"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:40:58.295786+00:00"}