{"created":"2023-06-19T07:37:23.141165+00:00","id":405,"links":{},"metadata":{"_buckets":{"deposit":"00dd9618-fd82-4539-8e92-03cb4d005909"},"_deposit":{"created_by":3,"id":"405","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"405"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000405","sets":["1:28:130"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The associations between periodontal disease and atherosclerosis-induced diseases"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"277","bibliographicPageStart":"255","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"During the last two decades, there has been increasing interest in the impact of periodontal disease on atherosclerosis and subsequent cardiovascular disease (CVD). However, due to the multi-factorial nature of periodontal disease as an oral infection and CVD, confirming a causal association is difficult, and the published results are conflicting. The main deficit in the majority of these studies has been the inadequate control of numerous confounding factors, leading to overestimation and imprecise measurement of the predictor or overadjustment for confounding variables, resulting in underestimation of the risks. In this paper, a literature search was performed to identify descriptive and cross-sectional studies, case-control studies, longitudinal studies, and systematic reviews and meta-analyse of prospective and retrospective follow-up studies as well as clinical trials addressing different aspects of periodontal disease (microbial, immunological) and clinical outcomes of CVD. A review of the knowledge of the effects of periodontal disease on the development of atheromatous plaque is presented here. There was no scientific evidence to prove direct association between periodontal disease and atherosclerosis. However, such a relationship appears probable in light of the reviewed articles. Recently, bacterial and viral organisms involved in chronic inflammatory processes have also been regarded as risk factors for atherosclerosis. The advent of the inflammation paradigm in the pathogenesis of atherosclerosis has stimulated research into chronic infections caused by a variety of micro-organisms-such as Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus-as well as dental pathogens. Moreover, these low grade chronic infections are thought to be involved in the etiopathogenesis of CVD by releasing cytokines and other pro-inflammatory mediators (e.g., C-reactive protein: CRP, serum amyloid A: SAA, tumor necrosis factor: TNF-α) that may initiate a cascade of biochemical reactions and cause endothelial damage and facilitate cholesterol plaque attachment. Periodontitis is one of the most common chronic bacterial infections. Overall, it appears that periodontal disease may indeed contribute to the pathogenesis of cardiovascular disease, although the statistical effect size remains small. In the future, reliable markers should be developed to accurately indicate the effect of periodontal disease on the condition of the arteries. This article focuses on reviewing studies that have looked for associations between periodontal disease and atherosclerosis-related diseases and discusses causal and noncausal explanations for these associations.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉成, 伸夫"},{"creatorName":"横井, 隆政"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-23"}],"displaytype":"detail","filename":"matsumoto_shigaku_34-03-01.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_34-03-01.pdf","url":"https://mdu.repo.nii.ac.jp/record/405/files/matsumoto_shigaku_34-03-01.pdf"},"version_id":"0b209199-2a1e-4e2c-bb61-af8a1d606f72"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯周病","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈硬化性疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"総説","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"歯周病と動脈硬化性疾患との関連性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"歯周病と動脈硬化性疾患との関連性"}]},"item_type_id":"2","owner":"3","path":["130"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-23"},"publish_date":"2012-05-23","publish_status":"0","recid":"405","relation_version_is_last":true,"title":["歯周病と動脈硬化性疾患との関連性"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:39:08.255466+00:00"}