@article{oai:mdu.repo.nii.ac.jp:00000429,
 author = {飯島, 曉子 and 奥村, 雅代 and 田中, 丈也 and 姫野, 勝仁 and 時崎, 匡史 and 金銅, 英二},
 issue = {3},
 journal = {松本歯学},
 month = {Dec},
 note = {application/pdf, This study investigated the involvement of a transcription factor STAT3 (signal transducer and activator of transcription 3) in acute inflammation of the maxillofacial area. We demonstrated localization of some inflammatory cytokine receptors and its downstream signal molecules, JAK (Janus kinases)-Tyk (Tyrosin kinase) family, in trigeminal ganglion (TG). Therefore, when the maxillofacial area is inflamed, it is expected that STAT3, a mediator of JAK/STAT signal transduction pathway, will be up-regulated in trigeminal ganglion neurons that innervate the irritated tissues. Acute inflammation was produced by capsaicin injection to serially the unilateral upper lip, and expression of STAT3 in TG after injection was observed over a 7-day. By immuno-histochemistry, STAT3-immunoreactivities (IR) were detected in small and medium size neurons, and the number of immunoreactive neurons increased both in the ipsi-and contra-lateral TG after injection. Immunoblot analysis showed that the total amount of STAT3 in TG did not change ipsilaterally, but was increased contralaterally. The amount of phosphorylated STAT3 was slightly increased in TG on both sides. These data suggest that STAT3 expression in the bilateral TG is regulated by unilateral acute inflammation.},
 pages = {291--298},
 title = {急性炎症時におけるサイトカインの関与 : 三叉神経節細胞でのSTAT3の変化},
 volume = {33},
 year = {2007}
}