{"created":"2023-06-19T07:37:24.421275+00:00","id":429,"links":{},"metadata":{"_buckets":{"deposit":"07c9e22c-6de5-430e-a184-538b84af7ebb"},"_deposit":{"created_by":3,"id":"429","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"429"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000429","sets":["1:29:127"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Involvement of cytokine intracelluIar molecules in the rat trigeminal ganglion under acute inflammation : A change of STAT3 molecules in the trigeminal ganglion"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"298","bibliographicPageStart":"291","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study investigated the involvement of a transcription factor STAT3 (signal transducer and activator of transcription 3) in acute inflammation of the maxillofacial area. We demonstrated localization of some inflammatory cytokine receptors and its downstream signal molecules, JAK (Janus kinases)-Tyk (Tyrosin kinase) family, in trigeminal ganglion (TG). Therefore, when the maxillofacial area is inflamed, it is expected that STAT3, a mediator of JAK/STAT signal transduction pathway, will be up-regulated in trigeminal ganglion neurons that innervate the irritated tissues. Acute inflammation was produced by capsaicin injection to serially the unilateral upper lip, and expression of STAT3 in TG after injection was observed over a 7-day. By immuno-histochemistry, STAT3-immunoreactivities (IR) were detected in small and medium size neurons, and the number of immunoreactive neurons increased both in the ipsi-and contra-lateral TG after injection. Immunoblot analysis showed that the total amount of STAT3 in TG did not change ipsilaterally, but was increased contralaterally. The amount of phosphorylated STAT3 was slightly increased in TG on both sides. These data suggest that STAT3 expression in the bilateral TG is regulated by unilateral acute inflammation.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"飯島, 曉子"},{"creatorName":"奥村, 雅代"},{"creatorName":"田中, 丈也"},{"creatorName":"姫野, 勝仁"},{"creatorName":"時崎, 匡史"},{"creatorName":"金銅, 英二"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_33-03-05.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_33-03-05.pdf","url":"https://mdu.repo.nii.ac.jp/record/429/files/matsumoto_shigaku_33-03-05.pdf"},"version_id":"bb9973fd-62b8-4483-8966-ea6eed6f7d97"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"三叉神経節細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"STAT3","subitem_subject_scheme":"Other"},{"subitem_subject":"セカンドメッセンジャー","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"急性炎症時におけるサイトカインの関与 : 三叉神経節細胞でのSTAT3の変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"急性炎症時におけるサイトカインの関与 : 三叉神経節細胞でのSTAT3の変化"}]},"item_type_id":"2","owner":"3","path":["127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"429","relation_version_is_last":true,"title":["急性炎症時におけるサイトカインの関与 : 三叉神経節細胞でのSTAT3の変化"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:38:33.120602+00:00"}