{"created":"2023-06-19T07:37:25.352303+00:00","id":443,"links":{},"metadata":{"_buckets":{"deposit":"664f9323-5920-4edb-86ec-15c1f3568094"},"_deposit":{"created_by":3,"id":"443","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"443"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000443","sets":["1:29:128"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Periodontal disease as a biofilm infectious disease: a hypothesis : Periodontal therapy by macrolide antibiotic"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"166","bibliographicPageStart":"157","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Caries and periodontal disease are two major oral diseases and are the infectious diseases due to dental plaques which are formed by intraoral bacteria. In 1999, Costerton proposed that they are biofilm infectious diseases. The systemic disorders due to biofilm include cystic fibrosis pneumonia and infective endocarditis. Biofilms are bacterial populations which are enclosed by extracellular matrix produced by bacteria per se and which adhere to each other and/or surfaces or interfaces such as medical devices. Importantly, bacteria in biofilm are resistant to antibiotics. Periodontal disease as a biofilm infectious disease is considered as below. Porphyromonas gingivalis is implicated in the initiation and progression or periodontitis. Periodontal disease-associated bacteria such as Porphyromonas gingivalis formed biofilm in periodontal pockets or on the surface of cementum. Planktonic bacteria from biofilm invade into periodontal tissues and lead to inflammation and destruction of tissues directly and indirectly by elicit host defense mechanism. Supragingival dental plaques are easily removed by professional mechanical tooth cleaning (PMTC), while subgingival biofilm and bacteria invading into periodontal tissues are difficult to be removed. Therefore, the development of novel methods for periodontal disease is needed to eliminate these biofilms efficiently. Recently, we examine the effect of azithromycin to in vitro biofilm model, which is made of Streptococcus gordonii and Porphyromonas gingivalis to confirm these clinical findings in vitro. Our results suggest that pharmacotherapy to destroy biofilm using antibiotics such as erythromycin and azithromycin is effective and necessary for the treatment of periodontal disease. In addition, our group demonstrated that systemic administration of azithromycin is clinically effective to the treatment of early-onset (aggressive) periodontitis and shorten the period of initial preparation. These results suggest that pharmacotherapy to destroy biofilm using antibiotics is effective and necessary for the treatment of periodontal disease.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"王, 宝禮"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_33-02-02.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_33-02-02.pdf","url":"https://mdu.repo.nii.ac.jp/record/443/files/matsumoto_shigaku_33-02-02.pdf"},"version_id":"fad91325-04e0-401d-929b-2909d7433d54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"バイオフィルム","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"抗菌薬","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"バイオフィルム感染症としての歯周病発症機序試論 : マクロライド系抗菌薬による歯周病薬物療法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"バイオフィルム感染症としての歯周病発症機序試論 : マクロライド系抗菌薬による歯周病薬物療法"}]},"item_type_id":"2","owner":"3","path":["128"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"443","relation_version_is_last":true,"title":["バイオフィルム感染症としての歯周病発症機序試論 : マクロライド系抗菌薬による歯周病薬物療法"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:38:07.620752+00:00"}