{"created":"2023-06-19T07:37:25.557329+00:00","id":446,"links":{},"metadata":{"_buckets":{"deposit":"5e743f7e-fce7-48c9-95d8-82ff796ef7b4"},"_deposit":{"created_by":3,"id":"446","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"446"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000446","sets":["1:29:128"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Inflammatory cytokines and internal resorption of human deciduous teeth prior to shedding"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"199","bibliographicPageStart":"187","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Prior to shedding of human deciduous, odontoclastic resorption takes place at the pulpal surface of the coronal dentin. The purpose of the present investigation was to study, immunohistochemically, the effect of inflammatory cytokines on this internal resorption of human deciduous teeth. Fifty-six human deciduous teeth (12 incisors, 18 canines, 26 molars) in the later stage of exfoliation were used in this study. Using anti-human IL-1α, IL-6, and TNF-α monoclonal antibodies, we elucidated the alteration in the distribution of various inflammatory cytokine-positive-cells in the pulp during the process of internal resorption. While the roots were being actively resorbed, there were no inflammatory cytokines positive cells in the pulp. However, when root resorption was nearly complete, numerous IL-1α-and TNF-α-positive cells started to infiltrate the coronal pulp. Then, odontoclasts were initially found on the surface of the predentin at the bottom areas of the pulp chamber. These gradually spread to the pulpal horn region along the wall of the pulp chamber. The inflammatory cytokines-positive cells in deciduous tooth pulp were increased with the progression of internal resorption, and were frequently found adjacent to odontoclasts. These findings suggest that various inflammatory cytokines play important roles in the migration, activation, and differentiation of odontoclasts during the internal resorption of human deciduous teeth prior to shedding.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石和田, 敏貴"},{"creatorName":"安東, 孝治"},{"creatorName":"森山, 敬太"},{"creatorName":"影山, 康子"},{"creatorName":"影山, 徹"},{"creatorName":"佐原, 紀行"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_33-02-04.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_33-02-04.pdf","url":"https://mdu.repo.nii.ac.jp/record/446/files/matsumoto_shigaku_33-02-04.pdf"},"version_id":"4af69f53-69f3-4cca-8d37-884ab3449992"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ヒト乳歯","subitem_subject_scheme":"Other"},{"subitem_subject":"内部吸收","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性サイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"破歯細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脱落前に認められるヒト乳歯の内部吸収と炎症性サイトカイン","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脱落前に認められるヒト乳歯の内部吸収と炎症性サイトカイン"}]},"item_type_id":"2","owner":"3","path":["128"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"446","relation_version_is_last":true,"title":["脱落前に認められるヒト乳歯の内部吸収と炎症性サイトカイン"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:38:10.718041+00:00"}