{"created":"2023-06-19T07:37:32.855395+00:00","id":559,"links":{},"metadata":{"_buckets":{"deposit":"4bbb9704-f34e-4bd2-811f-dd8342babca3"},"_deposit":{"created_by":3,"id":"559","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"559"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000559","sets":["1:32:121"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Mystery of osteoclasts"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-04-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"9","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deficiency of osteoprotegerin (OPG), a soluble decoy receptor for the receptor activator of NF-kB ligand (RANKL), in mice induces osteoporosis caused by enhanced bone resorption, but also accelerates bone formation. We examined whether bone formation is coupled with bone resorption in OPG-deficient (OPG^<-/->) mice delete using risedronate, an inhibitor of bone resorption. Histomorphometric analysis showed that bone formation-related parameters (e.g., mineral apposition rate and osteoblast surface/bone surface) in OPG^<-/-> mice sharply decreased with suppression of bone resorption by daily injection of risedronate for 30 days. OPG^<-/-> mice exhibited high serum alkaline phosphatase activity and osteocalcin concentration, both of which were decreased to the levels of wild-type mice by the risedronate injection. Serum levels of RANKL were markedly elevated in the OPG^<-/-> mice, but were unaffected by risedronate. These results suggest that bone formation is coupled with bone resorption at local sites in OPG^<-/-> mice, and that serum RANKL levels do not reflect this coupling.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 美どり"},{"creatorName":"松浦, 幸子"},{"creatorName":"宮沢, 裕夫"},{"creatorName":"宇田川, 信之"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_30-01-02.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_30-01-02.pdf","url":"https://mdu.repo.nii.ac.jp/record/559/files/matsumoto_shigaku_30-01-02.pdf"},"version_id":"4b3ca1f6-7e03-401f-af37-f6efd0de9aad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨化謝共役","subitem_subject_scheme":"Other"},{"subitem_subject":"破骨細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"OPG","subitem_subject_scheme":"Other"},{"subitem_subject":"大理石骨病","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"破骨細胞の神秘","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"破骨細胞の神秘"}]},"item_type_id":"2","owner":"3","path":["121"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"559","relation_version_is_last":true,"title":["破骨細胞の神秘"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:35:36.772940+00:00"}