@article{oai:mdu.repo.nii.ac.jp:00000583,
 author = {高橋, 直之},
 issue = {2},
 journal = {松本歯学},
 month = {Aug},
 note = {application/pdf, The recent discovery of receptor activator of NF-kB ligand (RANKL)-RANK interaction confirms the well-known hypothesis that osteoblasts play an essential role in osteoclast differentiation. Osteoblasts express RANKL, a tumor necrosis factor α(TNF-α) family member, as a membrane-associated factor. Osteoclast precursors that express RANK, a receptor for RANKL, recognize RANKL through the cell-cell interaction and differentiate into osteoclasts. Recent studies have shown that lipopolysaccharide and inflammatory cytokines such as TNF-α and interleukin 1 directly regulate osteoclast differentiation and function through a mechanism independent of the RANKL-RANK interaction. Interferon-γ and β are also shown to be important negative regulators in osteoclastogenesis. These findings have opened new areas for exploring the regulatory mechanisms of osteoclast differentiation and function. This review article describes the current knowledge of signal transduction which regulates osteoclast differentiation and function.},
 pages = {143--151},
 title = {破骨細胞の分化と機能を調節するシグナル伝達系},
 volume = {29},
 year = {2003}
}