{"created":"2023-06-19T07:37:34.472174+00:00","id":583,"links":{},"metadata":{"_buckets":{"deposit":"cad05f96-edcc-41f2-b7ed-f2f91fed93cd"},"_deposit":{"created_by":3,"id":"583","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"583"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000583","sets":["1:33:116"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Signal transduction which regulates osteoclast differentiation and function"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"151","bibliographicPageStart":"143","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The recent discovery of receptor activator of NF-kB ligand (RANKL)-RANK interaction confirms the well-known hypothesis that osteoblasts play an essential role in osteoclast differentiation. Osteoblasts express RANKL, a tumor necrosis factor α(TNF-α) family member, as a membrane-associated factor. Osteoclast precursors that express RANK, a receptor for RANKL, recognize RANKL through the cell-cell interaction and differentiate into osteoclasts. Recent studies have shown that lipopolysaccharide and inflammatory cytokines such as TNF-α and interleukin 1 directly regulate osteoclast differentiation and function through a mechanism independent of the RANKL-RANK interaction. Interferon-γ and β are also shown to be important negative regulators in osteoclastogenesis. These findings have opened new areas for exploring the regulatory mechanisms of osteoclast differentiation and function. This review article describes the current knowledge of signal transduction which regulates osteoclast differentiation and function.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 直之"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_29-02-01.pdf","filesize":[{"value":"625.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_29-02-01.pdf","url":"https://mdu.repo.nii.ac.jp/record/583/files/matsumoto_shigaku_29-02-01.pdf"},"version_id":"4377a194-904f-4596-9609-7ba19631db9e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"破骨細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"骨芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"},{"subitem_subject":"RANL, RANK","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"OPG","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"破骨細胞の分化と機能を調節するシグナル伝達系","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"破骨細胞の分化と機能を調節するシグナル伝達系"}]},"item_type_id":"2","owner":"3","path":["116"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"583","relation_version_is_last":true,"title":["破骨細胞の分化と機能を調節するシグナル伝達系"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:34:57.549020+00:00"}