{"created":"2023-06-19T07:37:04.003908+00:00","id":67,"links":{},"metadata":{"_buckets":{"deposit":"14b54136-e4e1-463c-ac4c-bb0fb0b4742a"},"_deposit":{"created_by":3,"id":"67","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"67"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000067","sets":["1:15:16"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The effect of Panax notoginseng on blood coagulation system"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"16","bibliographicPageStart":"9","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Panax notoginseng is used as a hemostatic drug to treat the dental extraction socket. However, the mechanisms remain to be elucidated. Therefore, the effects of Panax notoginseng on the blood coagulation system were examined in this study. Extraction of Panax notoginseng with phosphate-buffered saline (PBS) or PBS + bovine serum albumin (BSA) prolonged activated partial thromboplastin time (APTT), but had no effect on prothrombin time (PT). APTT by treatment with PBS+BSA-extraction was shorter than that with PBS-extraction. Heat treatment of PBS-extraction had no effect on APTT, but heat treatment of PBS+BSA-extraction reduced the effect of shortening of APTT compared to the control. Fifty percent of ethanol extraction of Panax notoginseng shortened APTT, while 100% ethanol extraction prolonged APTT. When 50% ethanol extraction (Fr.I) was fractionated, the ethyl acetate-soluble fraction (Fr.II) shortened APTT, but the n-butanol-soluble fraction (Fr.III) and the water-soluble fraction (Fr.IV) had no effect on APTT. These findings suggested that water-soluble components inhibit the intrinsic coagulation system, that the lipid-soluble components facilitate, and that both components were heat-stable. Moreover, the components facilitating the intrinsic coagulation system were present in Fr.I and in particular Fr.II. Therefore, both Fr.I and Fr.II may be applicable as a hemostatic drug.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"橋本, 洋幸"},{"creatorName":"荒, 敏昭"},{"creatorName":"藤波, 義明"},{"creatorName":"服部, 敏己"},{"creatorName":"王, 宝禮"},{"creatorName":"宮沢, 裕夫"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-22"}],"displaytype":"detail","filename":"matsumoto_shigaku_37-01-02.pdf","filesize":[{"value":"578.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_37-01-02.pdf","url":"https://mdu.repo.nii.ac.jp/record/67/files/matsumoto_shigaku_37-01-02.pdf"},"version_id":"1c0c6038-04eb-4594-8a80-9dbd9fe14201"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"田七","subitem_subject_scheme":"Other"},{"subitem_subject":"血液凝固","subitem_subject_scheme":"Other"},{"subitem_subject":"内因系","subitem_subject_scheme":"Other"},{"subitem_subject":"活性化部分トロンボプラスチン時間","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"血液凝固系に対する田七の作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血液凝固系に対する田七の作用"}]},"item_type_id":"2","owner":"3","path":["16"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-22"},"publish_date":"2012-05-22","publish_status":"0","recid":"67","relation_version_is_last":true,"title":["血液凝固系に対する田七の作用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:46:32.321397+00:00"}