{"created":"2023-06-19T07:37:42.118280+00:00","id":707,"links":{},"metadata":{"_buckets":{"deposit":"7ca985d2-bfd1-47df-92aa-579d1d1ba1c5"},"_deposit":{"created_by":3,"id":"707","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"707"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000707","sets":["1:37:107"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Taste Transduction Mechanisms in Mammals"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-04-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"20","bibliographicPageStart":"1","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This review describes the recent progress in the understanding of mammalian taste transduction mechanisms. Electrophysiological and biochemical studies have shown that taste cells use a variety of mechanisms for transducing taste stimuli into neural signals. i) A salty taste is transduced by an influx of Na^+ or some other alkali metal ions either through amiloride-sensitive Na^+ channels in the apical membranes of taste cells or through other Na^+ channels in the basolateral plasma membranes. ii) A sour taste is partly transduced by an influx of H^+ through the same amiloride-sensitive Na^+ channels as used for salty taste transduction and by other unknown mechanisms, which may involve unidentified H^+-gated cation channels. iii) A bitter taste is transduced by the binding of bitter substances to specific receptors on the taste cell membranes, which are coupled to second messenger-producing systems. One of the second messengers involved is inositol 1, 4, 5-trisphosphate (IP_3); others may be cyclic AMP and/or cyclic GMP. iv) A sweet taste is transduced, like the bitter taste, by the binding of sweet substances to the receptors coupled to systems producing second messengers such as cyclic AMP (or cyclic GMP) and IP_3. In some animals, sweet stimuli may cause an influx of external Na^+ by opening amiloride-sen-sitive Na^+ channels. A taste tissue-specific G protein α-subunit, α-gustducin, is believed to be involved in the transduction of both bitter and sweet tastes, the mechanism of which is yet to be elucidated. Bitter or sweet tasting amphiphilic molecules may penetrate taste cells and affect taste transduction systems directly from inside the cells. v) The transduction mechanism of 'umami' taste is not yet well understood, but a novel taste tissue-specific metabotropic glutamate receptor, mGluR4, is assumed to be working as a receptor for the taste of glutamate.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"浅沼, 直和"},{"creatorName":"安藤, 宏"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_25-01-01.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_25-01-01.pdf","url":"https://mdu.repo.nii.ac.jp/record/707/files/matsumoto_shigaku_25-01-01.pdf"},"version_id":"c0a58e3f-1da0-4b5b-b3e9-f0adec210f45"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"味覚","subitem_subject_scheme":"Other"},{"subitem_subject":"味細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"情報変換機序","subitem_subject_scheme":"Other"},{"subitem_subject":"哺乳動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"哺乳動物における味覚の情報変換機序","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"哺乳動物における味覚の情報変換機序"}]},"item_type_id":"2","owner":"3","path":["107"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"707","relation_version_is_last":true,"title":["哺乳動物における味覚の情報変換機序"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:31:56.294082+00:00"}