{"created":"2023-06-19T07:37:53.422079+00:00","id":881,"links":{},"metadata":{"_buckets":{"deposit":"63f4dd06-f012-4355-a3f4-3b1c05bd6938"},"_deposit":{"created_by":3,"id":"881","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"881"},"status":"published"},"_oai":{"id":"oai:mdu.repo.nii.ac.jp:00000881","sets":["1:137:140"]},"author_link":["0"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Immunocytochemical Localization of Catechol-O-Methyltransferase with Special Reference to Oral Tissue"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-04-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"13","bibliographicPageStart":"1","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Catechol-O-methyltrasnferase (COMT) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to one of the phenolic hydroxyl groups of a variety of catechols. This O-methylation reaction is important in the enzymatic inactivation of circulating catecholamines, the enzymatic inactivation of 2-hydroxyestrogens, the detoxification of xenobiotic catechols and the local inactivation of catecholamines released as transmitters from the terminals of both central and peripheral catecholamine-containing neurons. Many studies have shown that COMT is widely distributed in animals' tissues with the highest levels present in liver and kidney. COMT is an intracellular enzyme that is present predominantly in a soluble form with lesser amounts bound to membrane or microsomal fraction. Several specific antibodies to COMT have been available. Those permit us to examine the localization of COMT in the various organs of animals. COMT-positive cell was observed in the adrenal gland, brain, dental pulp, ductus deferens, gastrointestinal tract, eye, kidney, sublingual gland, liver, lymph node, mammary gland, ovary, oviduct, pancreas, parotid gland, pituitary gland, seminal vesicle, spinal cord, spinal ganglia, spleen, submandibular gland, sweat gland, thymus and uterus. COMT-positive reaction product in reactive cells was diffusely present throughout their ccytoplasm, but was absent from the nucleus. In the rat salivary gland, the myoepithelial and striated duct cells contained COMT. COMT was present in the macrophages like cells in the rat dental pulp. The possible functions of COMT in vivo have become more apparent with the expanding knowledge of the specific cellular localization.","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"松本歯科大学学会"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 勝博"}],"nameIdentifiers":[{"nameIdentifier":"0","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-05-24"}],"displaytype":"detail","filename":"matsumoto_shigaku_21-01-01.pdf","filesize":[{"value":"838.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsumoto_shigaku_21-01-01.pdf","url":"https://mdu.repo.nii.ac.jp/record/881/files/matsumoto_shigaku_21-01-01.pdf"},"version_id":"7bdd26cc-846d-4c24-8d37-985782f4e572"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"catechol-O-methyltransferase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunocytochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oral tissue","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カテコール-O-メチル基転移酵素の免疫組織学的局在 : 口腔組織との関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カテコール-O-メチル基転移酵素の免疫組織学的局在 : 口腔組織との関連"}]},"item_type_id":"2","owner":"3","path":["140"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"881","relation_version_is_last":true,"title":["カテコール-O-メチル基転移酵素の免疫組織学的局在 : 口腔組織との関連"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T08:27:24.589295+00:00"}